MAGNETIC RESONANCE AND COMPUTER TOMOGRAPHY IN THE DIAGNOSIS OF PRIMARY FALLOPIAN TUBE CANCER
Abstract
Primary fallopian tube cancer (PTC) is a rare, highly malignant and difficult to diagnose disease. It accounts for 1.3–1.8% of all cases of cancer of the female genital organs and at least 4–6% of cancer of the uterine appendages. Epidemiological studies indicate an increase in the incidence of PTС. For example, according to American authors, from 2001 to 2014, it increased 4 times. Clinical manifestations of PTС are nonspecific and in the early stages of development, the tumor is disguised as other diseases, such as hydro-hematosalpinx, chronic inflammatory diseases, ovarian-menstrual cycle disorders, uterine leiomyoma, and others. Even in specialized oncology hospitals, reliable preoperative diagnoses range from 0 to 10-13%, and in the general medical network, even during operations, false diagnoses reach 50%. Without additional methods of examination, it is almost impossible to make a reliable diagnosis of PTС before surgery. Previously, for the purpose of diagnosing primary fallopian tube cancer, X-ray methods were used, then sonography, and nowadays magnetic resonance tomography (MRT) and computer tomography (CT) have started to be used in parallel with sonography.
The aim of the study: to demonstrate cases of examination and diagnosis of primary fallopian tube cancer before surgery by MRT and to review the literature on the specified problem.
Materials and methods: the study was conducted on the basis of the Sumy Regional Clinical Oncology Dispensary during 2015-2022. Four patients were examined by the magnetic resonance method and 15 women by the computer tomography method; an analysis of 26 scientific sources of the world's periodical literature on the problems of MRІ diagnosis of PTC was carried out; statistical processing of the material.
Results and discussion: In almost two patients with primary fallopian tube cancer examined by MRT, correct diagnoses were made before surgery, and out of 15 examined by the CT method, only two cases revealed a suspicion of PTC.
Conclusions. In the diagnosis of primary fallopian tube cancer, MRT has significantly greater capabilities than sonography and computer tomography.
Downloads
References
Trabert B, Coburn SB, Mariani A, Yang P et al. Reported Incidence and Survival of Fallopian Tube Carcinomas: A Population-Based Analysis from the North American Association of Central Cancer Registries. J. Natl.Cancer Inst. 2018;110(7):750-757. https://doi.org/10.1093/jnci/djx263
Sumtsov DG, Gladchuk IZ, Sumtsov GO et al. Problems of primary fallopian tube cancer diagnostics during and after surgery. Reproductive Endocrinology. 2021; 3(59):66-71. https://doi.org/10.18370/2309-4117.2021.59.66-71
Kar T, Kar A, Dhal I, Panda S et al. Serous Tubal Carcinogenesis: The Recent Concept of Origin of Ovarian, Primary Peritoneal and Fallopian Tube High-Grade Serous Carcinoma. J Obstet Gynaecol India. 2017;67(6):432-441. https://doi.org/10.1007/s13224-017-1009-0. Epub 2017 Jun 1.10.
Liao CI, Chow S, Chen LM, et al.Trends in the incidence of serous fallopian tube, ovarian, andperitoneal cancer in the US. Gynecologic oncology. 2018;149(2):318–23. https://doi.org/10.1016/j.ygyno.2018.01.030.
Gayam S, Babu C, et al. Case report of primary serous adenocarcinoma of fallopian tube- adiagnostic dilemma. Obsgyne Review: J Obst Gynecol 4.4 (2018): 73–6. https://doi.org/10.17511/jobg.2018.i4.01.
Gungorduk K, Ertas IE, Ozdemir A, et al. Prognostic Significance of Retroperitoneal Lymphadenectomy, Preoperative Neutrophil Lymphocyte Ratio and Platelet Lymphocyte Ratio in Primary Fallopian Tube Carcinoma: A Multicenter Study. Cancer Res Treat. 2015 Jul;47(3):480-8. https://doi.org/10.4143/crt.2014.058.
Sumtsov GO, Sumtsov DG. Primary fallopian tube cancer: Monograph. Sumy: Sumy State University, 2015;229 p.
Thanasa E, Stamouli D, Gerokostas E-E et al. Primary Fallopian Tube Carcinoma: An Extremely Rare Gynecological Cancer Misdiagnosed Intraoperatively as Benign Ovarian Neoplasm: A Case Report. Clin. Pract. 2022; 12(3):253-260; https://doi.org/10.3390/clinpract12030030.
Shalini B, Shalini R, Sameer G. Primary fallopian tube carcinoma: Preoperative diagnostic dilemma Indian Journal of Health Sciences and Biomedical Research KLEU. 2023; 16(2):324-326. https://doi.org/10.4103/kleuhsj.kleuhsj_677_22
Sumtsov D., Gladchuk I., Kashtalian N., Sumtsov G. Practical means of preoperative diagnostics of primary fallopian tube cancer. Wiadomości Lekarskie. 2021; LXXIV(2):282-287. https://doi.org/10.36740/WLek202102120
Ma X, Huang X, Chen C, Ding Y. A Preliminary Report Requiring Continuation of Research to Confirm Fallopian Tube Adenocarcinoma: A Non-Experimental, Non-Randomized, Cross-Sectional Study. Med Sci Monit. 2018; 24:5301-5308. https://doi.org/10.12659/MSM.909661
Grabowska-Derlatka L, Szeszkowski W, Sieńko J, Derlatka P. Magnetic resonance diffusion-weighted imaging in diagnosticsof primary fallopian tube carcinoma – is it useful? Pol J Radiol. 2018; 83:161−165 https://doi.org/10.5114/pjr.2018.75
Foti PV, Ognibene N, Spadola S et al. Non-neoplastic diseases of the fallopian tube: MR imaging with emphasis on diffusion-weighted imaging. Insights Imaging. 2016;7(3):311-27. https://doi.org/10.1007/s13244-016-0484-7
Gomes FV, Dias JL, Lucas R, and Margarida T. Cunha Primary fallopian tube carcinoma: review of MR imaging findings. Insights Imaging. 2015; 6(4): 431–439. https://doi.org/10.1007/s13244-015-0416-y
Xiao Y, Xiao Z, Liu Z F. MRI can be used to differentiate between primary fallopian tube carcinoma and epithelial ovarian cancer. Clin. Radiol. 2020;75(6):457-465. https://doi.org/10.1016/j.crad.2020.02.002.
Ma FH, Cai SQ, Qiang JW et al. MRI for differentiating primary fallopian tube carcinoma from epithelial ovarian cancer. J Magn Reson Imag. 2015; 42: 42-47.
Winarto H and Fernando D. Identifying features of primary fallopian tube carcinoma using magnetic resonance imagingInt. Med Case Rep J. 2017; 10: 213–217. https://doi.org/10.2147/IMCRJ.S135836
Anthoulakis C, Nikoloudis N. Pelvic MRI as the “gold standard” in the subsequent evaluation of ultrasound-indeterminate adnexal lesions: a systematic review. Gynecol Oncol. 2014;132:661–668. https://doi.org/10.1016/j.ygyno.2013.10.022
Mao XF, Hu CH, Hu S et al: Magnetic resonance imaging features of fallopian tube carcinoma. Int J Gynaecol Obstet, 2015; 130: 204–46.
Singh N, Gilks CB, Wilkinson N, McCluggage WG. Assignment of primary site in high-grade serous tubal, ovarian and peritoneal carcinoma: a proposal. Histopathology. 2014;65:149–154. https://doi.org/10.1111/his.12419
Cai SQ, Ma FH, Qiang JW et al. Primary fallopian tube carcinoma: correlation between magnetic resonance and diffuse weighted imaging characteristics and histopathological findings. J Comput Assist Tomogr. 2014; 39: 270-275 https://doi.org/10.1097/RCT.0000000000000178
Ma FH , Cai SQ , Qiang JW al. MRI for differentiating primary fallopian tube carcinoma from epithelial ovarian cancer. J Magn Reson Imaging. 2015;42(1):42-7. https://doi.org/10.1002/jmri.24740
Kitai S, Kiyokawa T, Tanaka YO et al. MRI findings for primary fallopian tube cancer:correlation with pathological findings.Jpn J Radiol. 2018;36:134−141.
Zhou M, Lu B, Lv G, Tang Q et al. Differential diagnosis between metastatic and non-metastatic lymph nodes using DW-MRI: a meta-analysis of diagnostic accuracy stud. J Cancer Res Clin Oncol.. 2015;141(6):1119-30. https://doi.org/10.1007/s00432-014-1895-9
Gong Y, Wang Q, Dong L, Jia Y. et al. Different imaging techniques for the detection of pelvic lymph nodes metastasis from gynecological malignancies: a systematic review and meta-analysis. Oncotarget, 2017;8(8):14107-14125. https://doi.org/10.18632/oncotarget.12959 PMID: 27802186.
Rupa R, Prema R, Popat P B, Manchanda S et al. Imaging Recommendations for Diagnosis, Staging, and Management of Ovarian and Fallopian Tube Cancers. Ind J Med Paediatr Oncol 2023;44:100–109. https://doi.org/10.1016/j.jcma.2013.06.010

























