THE DEPENDENCE OF CHANGES IN LABORATORY INDICATORS ON ACCOMPANYING PATHOLOGY IN PATIENTS WITH VIRAL HEPATITIS C
Abstract
Objective: to determine the dependence of changes in hematological, biochemical indicators and indexes of nonspecific reactivity, inflammation, endogenous intoxication on accompanying pathology in patients with chronic viral hepatitis C (HCV).
Materials and methods: hematological, biochemical, non-specific immunological changes were analyzed in 20 chronic HCV patients without cardiovascular system pathologies, in 20 chronic HCV patients with concomitant coronary heart disease (CHD), in 20 people with coronary heart disease and arterial hypertension, and in 40 healthy people. Statistical analysis was carried out using IBM SPSS Statistics and Microsoft Office Excel 2016 programs with the calculation of non-parametric criteria.
Results: men with minimal hepatitis C virus (HCV) activity predominated among the patients. The majority of patients without accompanying pathologies were young, and those with arterial hypertension and coronary heart disease were elderly. In patients with viral hepatitis C, persons with concomitant cardiovascular pathology (ischemic heart disease and arterial hypertension), the following was observed: a decrease in the content of platelets, erythrocytes; increase in the number of rod neutrophils, ESR, de Ritis coefficient; an increase in the integral index of severity, indices of non-specific immunoreactivity (RC, IRI, IRLM, Ilymph) and endogenous intoxication (HII and II). Also, in these patients, the levels of platelets and lymphocytes were reduced against the background of an increased level of II compared to patients who had viral hepatitis C with only hypertension.
Conclusions: in patients with chronic viral hepatitis C, who have arterial hypertension and coronary heart disease, there is a decrease in the content of platelets, erythrocytes and an increase in rod-shaped neutrophils, ESR, de Ritis coefficient, integral indicators of severity, indices of non-specific immunoreactivity and endogenous intoxication in comparison with patients without coronary heart disease and patients with chronic HCV only.
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References
World Health Organisation. Hepatitis Summit 2022 statement. Retrieved from: https://www.who.int/news/item/10-06-2022-world-hepatitis-summit-2022-statement
World Health Organisation. Global hepatitis report, 2017. Retrieved from: https://www.who.int/publications/i/item/9789241565455
World Health Organisation. Hepatitis C, 2022. Retrieved from: http://surl.li/sduqj
Tsentr hromadskoho zdorovia MOZ Ukrainy. Statystyka z virusnykh hepatytiv. [Statistics on viral hepatitis]. Retrieved from: https://www.phc.org.ua/kontrol-zakhvoryuvan/virusni-gepatiti/statistika-z-vg
Nevola R, Acierno C, Pafundi PC, Adinolfi LE. Chronic hepatitis C infection induces cardiovascular disease and type 2 diabetes: mechanisms and management. Minerva Med. 2021;112(2):188-200. https://doi.org/10.23736/S0026-4806.20.07129-3. PMID: 33205641
Pizzolo F, Castagna A, Olivieri O, Girelli D, Friso S, Stefanoni F, Udali S, Munerotto V, Baroni M, Cetera V, Luciani GB, Faggian G, Bernardi F, Martinelli N. Basophil Blood Cell Count Is Associated With Enhanced Factor II Plasma Coagulant Activity and Increased Risk of Mortality in Patients With Stable Coronary Artery Disease: Not Only Neutrophils as Prognostic Marker in Ischemic Heart Disease. J Am Heart Assoc. 2021;10(5):e018243. https://doi.org/10.1161/JAHA.120.018243. Epub 2021 Feb 24. PMID: 33624506; PMCID: PMC8174269
Kong P, Cui ZY, Huang XF, Zhang DD, Guo RJ, Han M. Inflammation and atherosclerosis: signaling pathways and therapeutic intervention. Signal Transduct Target Ther. 2022;7(1):131. https://doi.org/10.1038/s41392-022-00955-7. PMID: 35459215; PMCID: PMC9033871
Peng H, Wang S, Wang M, Ye Y, Xue E, Chen X, Wang X, Fan M, Gao W, Qin X, Wu Y, Chen D, Li J, Hu Y, Wang L, Wu T. Nonalcoholic fatty liver disease and cardiovascular diseases: A Mendelian randomization study. Metabolism. 2022;133:155220. https://doi.org/10.1016/j.metabol.2022.155220. Epub 2022 May 23. PMID: 35618017
Gîrleanu I, Trifan A, Huiban L, Muzîca C, Petrea OC, Sîngeap AM, Cojocariu C, Chiriac S, Cuciureanu T, Costache II, Stanciu C. Ischemic Heart Disease and Liver Cirrhosis: Adding Insult to Injury. Life (Basel). 2022;12(7):1036. https://doi.org/10.3390/life12071036. PMID: 35888123; PMCID: PMC9315506
Rajewski P, Zarębska-Michaluk D, Janczewska E, Gietka A, Mazur W, Tudrujek-Zdunek M, Tomasiewicz K, Belica-Wdowik T, Baka-Ćwierz B, Dybowska D, Halota W, Lorenc B, Sitko M, Garlicki A, Berak H, Horban A, Orłowska I, Simon K, Socha Ł, Wawrzynowicz-Syczewska M, Jaroszewicz J, Deroń Z, Czauż-Andrzejuk A, Citko J, Krygier R, Piekarska A, Laurans Ł, Dobracki W, Białkowska J, Tronina O, Wietlicka-Piszcz M, Pawłowska M, Flisiak R. Hepatitis C Infection as a Risk Factor for Hypertension and Cardiovascular Diseases: An EpiTer Multicenter Study. J Clin Med. 2022;11(17):5193. https://doi.org/10.3390/jcm11175193. PMID: 36079122; PMCID: PMC9456581
Chemych MD, Lishnevska AG. The role of galectin-9 in patients with chronic viral hepatitis C and its connection with the type of therapy, the degree of fibrosis, clinical, laboratory, autoimmune and integrative indicators. Wiad Lek. 2021;74(5):1180-1188.
Lishnevska AH, Chemych MD. Changes in clinical, biochemical, immunological and integrative parameters in patients with chronic hepatitis C virus infection according to the virus genotype and the grade of activity. Zaporozhye Medical Journal. 2020; 22(4), 485-494. https://doi.org/10.14739/2310-1210.2020.4.208363
Lishnevska A, Chemych M, Chemych O, Chernetsky I. Immunoreactivity and intoxication syndrome in patients with chronic viral hepatitis С. Bangladesh Journal of Medical Science. 2023; 22 (3): 508 – 514.
Iorga RA, Bacalbasa N, Bratu OG, Ionita Radu F, Diaconu CC. The impact of infection with hepatitis C virus on cardiovascular risk. Am J Cardiovasc Dis. 2020;10(3):201-206.
El Hadi H, Di Vincenzo A, Vettor R, Rossato M. Relationship between Heart Disease and Liver Disease: A Two-Way Street. Cells. 2020;9(3):567. https://doi.org/10.3390/cells9030567. PMID: 32121065; PMCID: PMC7140474
Sadighi Akha AA. Aging and the immune system: An overview. J Immunol Methods. 2018;463:21-26. https://doi.org/10.1016/j.jim.2018.08.005. PMID: 30114401
Döring Y, Libby P, Soehnlein O. Neutrophil Extracellular Traps Participate in Cardiovascular Diseases: Recent Experimental and Clinical Insights. Circ Res. 2020;126(9):1228-1241. https://doi.org/10.1161/CIRCRESAHA.120.315931. PMID: 32324499; PMCID: PMC7185047
Faber J, Hvas AM, Kristensen SD, Grove EL, Adelborg K. Immature Platelets and Risk of Cardiovascular Events among Patients with Ischemic Heart Disease: A Systematic Review. Thromb Haemost. 2021;121(5):659-675. https://doi.org/10.1055/s-0040-1721386. PMID: 33302302
Sao R, Aronow WS. Association of non-alcoholic fatty liver disease with cardiovascular disease and subclinical atherosclerosis. Arch Med Sci. 2018;14(6):1233-1244. https://doi.org/10.5114/aoms.2017.68821. Epub 2017 Jul 5. PMID: 30393477; PMCID: PMC6209727
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