DETERMINATION OF THE INFLUENCE MECHANISMS OF SUCCINIC ACID-BASED DRUG ON IMPROVING THE STATE OF ERYTHROCYTE LINK OF OXYGEN TRANSPORT DURING AEROBIC PHYSICAL LOADS

Keywords: aerobic loads, succinic acid, oxygen transport function of blood, erythrocyte membranes, lipid peroxidation

Abstract

Introduction. Strenuous aerobic work inherent to cyclical sports requires adequate oxygenation of the athletes’ working muscles. One of the ways to improve the oxygen transport function of blood is to optimize the structural and functional state of erythrocytes, for example, by using succinic acid in the form of the medical drug Armadin Long. This pharmacological drug is widespread in clinical practice for treating hypoxic and ischemic conditions, and very little is known about its use for improving the condition of the erythrocytes in the blood of athletes, which determined the relevance of this study.

The objective of the study was to assess the feasibility and effectiveness of using the medical drug Armadine Long to improve the state of the erythrocyte link of the blood oxygen transport system during aerobic exercise.

Materials and Methods. A randomized blinded placebo-controlled trial included 40 male middle-distance runners (aerobic discipline of athletics). The subjects were divided into two subgroups matched for number, age, and anthropometric characteristics (strats). In this work, laboratory methods were used, including hematological tests (in particular, hemoglobin and erythrocytes level measurement and erythrocyte characteristics evaluation), as well as biochemical method: the study of prooxidant and antioxidant balance (activity of lipid peroxidation according to changes in the content of maloniс dialdehyde and antioxidant protection according to changes in the concentration of reduced glutathione) and functional characteristics of erythrocyte membranes (permeability, sorption capacity, sorption capacity of the glycocalyx) as well as evaluation of the main components of lipid and protein composition of red blood cell membranes. Pedagogical research methods were based on the determination of relative aerobic capacity using the generally accepted PWC170 test.

Results of the study. During 21 days of intensive loads, an almost two-fold increase in contents of malonic dialdehyde was observed with a parallel decrease in reduced glutathione content by 23.5 % during aerobic loads. At the same time, there was a deterioration of the functional characteristics of erythrocytes and a decrease in the relative aerobic capacity in comparison with the baseline data.

The use of the medical drug Armadine Long at a dose of 600 mg per day improved the indicated characteristics of erythrocytes. At the same time, there were positive changes in the protein and lipid state of the erythrocyte membranes, and the athletes’ aerobic power increased by 38.7%. It substantiates the high ergogenic ability of succinic acid, which is based on the normalization of the lipoperoxidation process and the improvement of the structural and functional characteristics of erythrocyte membranes.

Author Biographies

Larisa Gunina, Educational and Scientific Olympic Institute, National Ukraine University of Physical Education and Sports, Kyiv, Ukraine

Deputy Director for Scientific and Pedagogical Work of the Educational and Scientific Olympic Institute, Doctor of Biological Sciences, Professor, National Ukraine University of Physical Education and Sports, Kyiv, Ukraine (https://orcid.org/0000-0003-2107-0983), e-mail: gunina.sport@gmail.com

Yurii Ataman, Department of Physical Therapy, Occupational Therapy, and Sports Medicine of the Medical Institute, Sumy State University, Sumy, Ukraine

Head of the Department of Physical Endurance, Occupational Therapy and Sports Medicine of the Medical Institute, Doctor of Medical Sciences, Professor, Sumy State University, Sumy, Ukraine (https://orcid.org/0000-0002-6398-1016), e-email: sportmed@med.sumdu.edu.ua

Ihor Belenichev, Department of Pharmacology and Medical Formulation with a Course of Normal Physiology, Zaporizhzhia Medical University, Zaporizhzhia, Ukraine

Head of the Department of Pharmacology and Medical Formulation with a Course of Normal Physiology, Doctor of Medical Sciences, Professor, Zaporizhzhia Medical University, Zaporizhzhia, Ukraine (https://orcid.org/0000-0003-1273-5314), e-mail: i.belenichev1914@gmail.com

Roman Golovashchenko, Department of Physical Education, Sports, and Health, State Tax University, Irpin, Ukraine

acting Head of the Department of Physical Education, Sports and Health, Candidate of Sciences in Physical Education and Sports, Associate Professor, State Tax University, Irpin, Ukraine (https://orcid.org/0000-0002-7607-1943), e-mail: romagolovaschenko@gmail.com

Valentina Voitenko, Department of Physical Therapy, Occupational Therapy, and Sports Medicine of the Medical Institute, Sumy State University, Sumy, Ukraine

assistant professor of the Department of Physical Endurance, Occupational Therapy and Sports Medicine of the Medical Institute, Doctor of Philosophy in Biological Sciences, Sumy State University, Sumy, Ukraine (https://orcid.org/0000-0002-3911-8116), e-mail: valiushka.voitenko@gmail.com

Victoria Bezugla, Educational and Scientific Olympic Institute, National Ukraine University of Physical Education and Sports, Kyiv, Ukraine

teacher of the Department of Physical Therapy and Occupational Therapy, National Ukraine University of Physical Education and Sports, Kyiv, Ukraine (https://orcid.org/0000-0002-3368-5494), e-mail: victoriabezugla@gmail.com

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Published
2022-09-30
How to Cite
Larisa Gunina, Yurii Ataman, Ihor Belenichev, Roman Golovashchenko, Valentina Voitenko, & Victoria Bezugla. (2022). DETERMINATION OF THE INFLUENCE MECHANISMS OF SUCCINIC ACID-BASED DRUG ON IMPROVING THE STATE OF ERYTHROCYTE LINK OF OXYGEN TRANSPORT DURING AEROBIC PHYSICAL LOADS. Eastern Ukrainian Medical Journal, 10(3), 247-258. https://doi.org/10.21272/eumj.2022;10(3):247-258