CORRELATIONS OF BODY MASS INDEX WITH CLINICAL AND LABORATORY INDICATORS IN PATIENTS WITH ESSENTIAL ARTERIAL HYPERTENSION DEPENDING ON AGT (RS699) GENE POLYMORPHISM
The aim. To analyze the correlations between body mass index (BMI) and clinical and laboratory parameters in patients with essential hypertension (EAH) depending on AGT gene (rs699) polymorphism.
Materials and methods. The case-control study involved 72 patients with stage II EAH, 1–3 degrees of blood pressure (BP), high and very high cardiovascular risk (CVD) (29.16% (21) men, 70.84% (51) women). The mean age of patients was 59.87 ± 7.98 y.o. The control group consisted of 48 healthy individuals comparable in age and gender. Polymorphism of the AGT gene (rs699) was detected by polymerase chain reaction. BMI was defined as the ratio of weight to square of height (kg/m2).
Results. The correlation matrix showed a direct relationship between BMI and anthropometric parameters of waist circumference (WC), hip circumference (HC) and WC/HC ratio (r = 0.70–0.81; p ≤ 0.022), vitamin D level (r = 0,65; p = 0.043) and the reverse with the level of ionized Ca2+ in the blood (r = -0.71; p = 0.02) among TT-genotype carriers; in TC-genotype carriers BMI was directly related to WC and HC (r = 0.68; p < 0.001 and r = 0.84; p < 0.001), as well as the level of parathyroid hormone (PTH) (r = 0,43; p = 0.004), with a negative correlation with the level of vitamin D (r = -0.38; p = 0.011); in CC-genotype carriers, a direct link was found between BMI and WC and HC (r = 0.73; p < 0.001 and r = 0.78; p < 0.001).
Conclusions. Thus, the correlation matrix showed that BMI directly depended on the anthropometric parameters of WC, HC and/or WC/HC (r = 0.68-0.84; p ≤ 0.022-0.001) regardless of the AGT gene genotypes (r = 0,52-0.86; p ≤ 0.02-0.001) and inversely correlated with the ionized Ca2+ level in the blood (r = -0.71; p = 0.02), but only in TT-genotype carriers of the AGT gene (rs699).
2. Semianiv M, Sydorchuk L. Clinical and metabolic parameters, Ca2+, parathormone depending on serum 25 (OH) D concentration in hypertensive patients in the West-Ukrainian population. Journal of Education, Health and Sport. 2021;11(12):150-157.
3. Kolland M, Kirsch A. Arterial hypertension and obesity. JOURNAL FUR HYPERTONIE. 2020;24(2):41-44.
4. Ruilope LM, Nunes Filho ACB, Nadruz W Jr, Rodríguez Rosales FF, Verdejo-Paris J. Obesity and hypertension in Latin America: Current perspectives. Hipertens Riesgo Vasc. 2018 Apr-Jun;35(2):70-76.
5. Fantin F, Giani A, Zoico E, Rossi AP, Mazzali G, Zamboni M. Weight Loss and Hypertension in Obese Subjects. Nutrients. 2019 Jul 21;11(7):1667.
6. Seravalle G, Grassi G. Obesity and hypertension. Pharmacol Res. 2017 Aug;122:1-7.
7. Saliba LJ, Maffett S. Hypertensive Heart Disease and Obesity: A Review. Heart Fail Clin. 2019 Oct;15(4):509-517.
8. Repchuk Y, Sydorchuk LP, Sydorchuk AR, et al. Linkage of blood pressure, obesity and diabetes mellitus with angiotensinogen gene (AGT 704T>C/rs699) polymorphism in hypertensive patients. Bratisl Lek Listy. 2021;122(10):715-720.
9. Susic D, Varagic J. Obesity: A Perspective from Hypertension. Med Clin North Am. 2017 Jan;101(1):139-157..
10. Repchuk Y, Sydorchuk L, Fedoniuk L, Nebesna Z, Vasiuk V, Sydorchukv A, Iftoda O. Association of Lipids’ Metabolism with Vitamin D Receptor (rs10735810, rs222857) and Angiotensinogen (rs699) Genes Polymorphism in Essential Hypertensive Patients. Open Access Macedonian Journal of Medical Science. 2021; 9(A):1052–1056.
11. Lelis DF, Pereira AC, Krieger JE, Mill JG, Santos SHS, Baldo MP. Polymorphisms of the renin-angiotensin system are not associated with overweight and obesity in a general adult population. Arch Endocrinol Metab. 2019;63(4):402-410.
12. Prat-Larquemin L, Oppert JM, Clément K, et al. Adipose angiotensinogen secretion, blood pressure, and AGT M235T polymorphism in obese patients. Obes Res. 2004;12(3):556-561.
13. Fang YJ, Deng HB, Thomas GN, et al. Linkage of angiotensinogen gene polymorphisms with hypertension in a sibling study of Hong Kong Chinese. J Hypertens. 2010;28(6):1203-1209.
14. Takakura Y, Yoshida T, Yoshioka K, Umekawa T, Kogure A, Toda H, Kagawa K, Fukui S, Yoshikawa T. Angiotensinogen gene polymorphism (Met235Thr) influences visceral obesity and insulin resistance in obese Japanese women. Metabolism. 2006; 55: 819–824.
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