PECULIARITIES OF TREATMENT OF CERVICAL SPINAL NERVE TUMORS WITH PARAVERTEBRAL EXTENSION
Abstract
Introduction. To evaluate the results of surgical treatment of patients with malignant peripheral nerve sheath tumors (MNST) with specification of the peculiarities of their structure and extension pattern, and to determine prognostically unfavorable morphological features in malignant tumors of peripheral nerves.
Materials and methods. The study is based on a retrospective analysis of the medical records of 48 patients. The indication for the operation was worsening neurological symptoms as a result of the tumor process in the cervical spine, verified by methods of neuroimaging (spondylography, CT, SCT, MRI).
Results. he expected response to surgical treatment in patients with MPNST depends on many factors: localization, directions of neoplasm extension, radical nature of the treatment and the histological variant of the tumor. In most cases, MNST is diagnosed in patients aged 27 to 56 years. The time from the onset of neurological symptoms to diagnosis varies from several weeks to one year.
Conclusions. Determining the tactics of surgery and the choice of surgical access is an important component for achieving long remission. The choice of an adequate approach makes it possible to totally remove the tumor, reduces the time of intervention, blood loss, injuries to the nervous structures during removal of the tumor.
Downloads
References
2. 2.Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK, Ohgaki H, Wiestler OD, Kleihues P, Ellison DW. The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. Acta Neuropathol. 2016 Jun;131(6):803-20. doi: 10.1007/s00401-016-1545-1. PubMed PMID: 27157931.
3. 3: Asano K, Yoshida G, Morita D, Ito T, Shido Y, Kouyama A, Iwase T, Matsuyama Y. Malignant peripheral nerve sheath tumor in the cervical spine with multiple nevus cell nevi. J Orthop Sci. 2016 Mar;21(2):250-4. doi: 10.1016/j.jos.2015.06.015. PubMed PMID: 26740424.
4. Sangala JR, Park P, Blaivas M, Lamarca F. Paraspinal malignant ossifying fibromyxoid tumor with spinal involvement. J Clin Neurosci. 2010 Dec;17(12):1592-4. doi: 10.1016/j.jocn.2010.04.022. PubMed PMID: 20801659.
5. Slomiany MG, Dai L, Bomar PA, Knackstedt TJ, Kranc DA, Tolliver L, Maria BL, Toole BP. Abrogating drug resistance in malignant peripheral nerve sheath tumors by disrupting hyaluronan-CD44 interactions with small hyaluronan oligosaccharides. Cancer Res. 2009 Jun 15;69(12):4992-8. doi: 10.1158/0008-5472.CAN-09-0143. PubMed PMID: 19470767; PubMed Central PMCID: PMC3655760.

This work is licensed under a Creative Commons Attribution 4.0 International License.

























