Oncological incidence of testicular cancer is the current medical and social problem in Ukraine and in the world. Despite the relatively low incidence rate for this pathology, it is of fundamental importance for clinicians, since it is the most common type of malignant tumors in young men of working age (15–45 years). In particular, the incidence of testicular cancer in Sumy region slightly differs from the national average. That is why the objective of our study was to analyze the level of testicular neoplasia among the population of Sumy region and Ukraine in 2011–2019, as well as to compare them. Based on the obtained data, Sumy region is included in the group of regions of Ukraine with an over-threshold incidence of testicular cancer. Statistical data analysis showed a tendency to a decrease of the overall incidence of testicular cancer among the adult population in Ukraine during the study period (on average, 2.55 per 100,000 population). At the same time, in Sumy region, there was a gradual increase in the frequency of cases of this oncopathology in men with the highest indicators reached in 2017 (4.33 per 100,000 population). Consequently, in Ukraine, this pathology affected men mainly at the age of 35–39. However, it is should be noted that the age range of morbidity in Sumy region was somewhat broader and mainly affected the population aged 30–39, and, in some years –men at the age of 20–29. It was established that testicular cancer affects the pediatric population, although it is extremely rare. Considering that seminoma is the most common type of testicular tumors, we focused on an in-depth study of its morphological features. Statistical data analysis revealed a link between the incidence of testicular cancer and the age of the male population. An important element of the research is the study of etiopathological factors that affect the growth of the degree of involvement, caused by this pathology.
2. Bondar HV, Dumansʹkyy, YUV, Popovych OYU. Onkolohiya [Oncology]. Kyiv: Medytsyna Publ, 2013. pp. 436-42.
3. Bray F, Ferley F, Soerjomataram I. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clinicians. 2018;68(6):394–424. doi: 10.3322/caac.21492
4. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2018. CA Cancer J Сlin 2018;68(1):7–30. Retrieved from: https://www.ncbi.nlm.nih.gov/pubmed/29313949 doi: 10.3322/caac.21442
5. Albers P, Albrecht W, Algaba F, Bokemeyer C, Cohn-Cedermark G, Fizazi K, Horwich A, Laguna MP, Nicolai N, Oldenburg J; European Association of Urology. Guidelines on Testicular Cancer: 2015 Update. Eur Urol. 2015;68(6):1054-68. doi: 10.1016/j.eururo.2015.07.044 PMID: 26297604
6. Wild CP, Weiderpass E, Stewart BW. World cancer report: cancer research for cancer prevention. International Agency for Research on Cancer. 2020;430-8. Retrieved from: https://shop.iarc.fr/products/world-cancer-report-cancer-research-for-cancer-prevention-pdf
7. Kheffner L. Polovaya sistema v norme i patologii [The reproductive system is normal and in pathology]. Moskva: Geotar-Med Publ, 2013. pp.104-5.
8. Trama A, Foschi R, Larranaga N, Sant M, Fuentes-Raspall R, Serraino D. Survival of male genital cancers (prostate, testis and penis) in Europe 1999-2007: results from the EUROCARE-5 study. Eur J Cancer. 2015;51(15):206–16. Retrieved from: https://www.ncbi.nlm.nih.gov/pubmed/26421823 doi: 10.1016/j.ejca.2015.07.027
9. Romanyuk AM, Sikora VV, Lyndin MS, Sikora VV, Piddubnyy AM. [Environmental factors resulting in urinary bladder pathology]. Aktualʹni problemy suchasnoyi medytsyny. 2016;16(53):146-60.
10. Lyndin MS, Kravtsova OI, Karpenko LI, Panchenko VD, Romanyuk AM. [Epidemiology and morphology investigation of corpus uteri malignant tumors]. Art of medicine. 2018;3:66-71.
11. Park JS, Kim J, Elghiaty A, Ham WS. Recent global trends in testicular cancer incidence and mortality. Medicine. 2018;97(37):e12390. Retrieved from: https://www.ncbi.nlm.nih.gov/pubmed/30213007 doi: 10.1097/MD.0000000000012390 PMID: 30213007
12. Romaniuk A, Lyndin M, Sikora V, Romaniuk S, Sikora K. Heavy metals effects on breast cancer progression. Journal of Occupational Medicine and Toxicology. 2017;12:32. Retrieved from: https://occup-med.biomedcentral.com/articles/10.1186/s12995-017-0178-1
13. Romaniuk A, Lyndin M, Moskalenko R, Gortinskaya O, Lyndina Y. The role of heavy metal salts in pathological biomineralization of breast cancer tissue. Advances in Clinical and Experemental Medicine. 2016;25(5):907-910. doi: 10.17219/acem/34472
14. Romaniuk A, Lyndin M, Moskalenko R, Gladchenko O, Lyndina Y. Pathogenetic mechanisms of heavy metals effect on proapoptotic and proliferative potential of breast cancer. Medicine. 2015;7(2):63–68. Retrieved from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464767/ doi: 10.1556/1646.7.2015.2.4 PMID: 26120478
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