THE POTENTIAL IMPACT OF VITAMIN D ON THE REDUCTION OF C-REACTIVE PROTEIN (CRP) LEVELS IN PATIENTS INFECTED WITH COVID-19
DOI:
https://doi.org/10.21272/eumj.2025;13(2):544-550Keywords:
lymphocyte; C-reactive protein; WBC; vitamin D; COVID-19Abstract
Introduction. Vitamin D reduces illness-related inflammation and boosts the immune system. COVID-19 has aroused debate and requires substantial scientific research to produce an effective defence against distinct coronavirus strains. In COVID-19 patients, vitamin D and C‑reactive protein levels were compared. Three months before the PCR test, vitamin D and C-reactive protein levels were assessed. These individuals' clinical results were also examined.
Aim. Investigation of the ability of vitamin D to mitigate C‑reactive protein levels in individuals with COVID-19
Materials and Methods. For the purpose of this cohort study, instances of COVID-19 were analyzed and differentiated into four distinct groups according to the levels of vitamin D that they possessed. Groups I through IV were classified according to the following parameters: concentration of 0–10 ng/ml, 10–20 ng/ml, 20–30 ng/ml, and greater than 30 ng/ml. These values served as the basis for the categorization of the samples. In order to determine the levels of vitamin D and C-reactive protein, the study used a method that had been clinically verified and was also automated.
Results. The prevalence of COVID-19 was highest in the vitamin D-deficient group. Higher vitamin D levels were associated with reduced COVID-19 severity, a positive correlation with lymphocyte proportion, and a negative correlation with white blood cells and CRP.
Conclusion. Vitamin D levels are inversely correlated with CRP levels and disease severity in COVID-19 patients. Vitamin D may serve as a potential biomarker for monitoring COVID-19 progression and warrants further investigation for its therapeutic implications.
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Yuen KS, Ye ZW, Fung SY, Chan CP, Jin DY. SARS-CoV-2 and COVID-19: The most important research questions. Cell Biosci. 2020; 10:1-5. https://doi.org/10.1186/s13578-020-00404-4
Iannaccone G, Scacciavillani R, Del Buono MG, Camilli M, Ronco C, Lavie CJ, Abbate A, Crea F, Massetti M, Aspromonte N. Weathering the cytokine storm in COVID-19: therapeutic implications. Cardiorenal medicine. 2020; 10(5):277-87. https://doi.org/10.1159/000509483
Amrein K, Scherkl M, Hoffmann M, Neuwersch-Sommeregger S, Köstenberger M, Tmava Berisha A, Martucci G, Pilz S, Malle O. Vitamin D deficiency 2.0: an update on the current status worldwide. European journal of clinical nutrition. 2020 Nov;74(11):1498-513. https://doi.org/10.1038/s41430-020-0558-y.
Lehmann U, Gjessing HR, Hirche F, Mueller-Belecke A, Gudbrandsen OA, Ueland PM, Mellgren G, Lauritzen L, Lindqvist H, Hansen AL, Erkkilä AT. Efficacy of fish intake on vitamin D status: a meta-analysis of randomized controlled trials. The American journal of clinical nutrition. 2015 Oct 1; 102(4):837-47. https://doi.org/10.3945/ajcn.114.105395
Del Pinto R, Pietropaoli D, Chandar AK, Ferri C, Cominelli F. Association between inflammatory bowel disease and vitamin D deficiency: a systematic review and meta-analysis. Inflammatory bowel diseases. 2015 Nov 1;21(11):2708-17. https://doi.org/10.1097%2FMIB.0000000000000546
Grant WB, Lahore H, McDonnell SL, Baggerly CA, French CB, Aliano JL, Bhattoa HP. Evidence that vitamin D supplementation could reduce risk of influenza and COVID-19 infections and deaths. Nutrients. 2020 Apr;12(4):988. https://doi.org/10.3390/nu12040988
Zhou A, Hyppönen E. Vitamin D deficiency and C-reactive protein: a bidirectional Mendelian randomization study. International Journal of Epidemiology. 2023; 52(1):260-71. https://doi.org/10.1093/ije/dyac087
Hu J, Ge H, Newman M, Liu K. OSA: a fast and accurate alignment tool for RNA-Seq. Bioinformatics. 2012 Jul 15; 28(14):1933-4. https://doi.org/10.1093/bioinformatics/bts294
Meltzer DO, Best TJ, Zhang H, Vokes T, Arora V, Solway J. Association of vitamin D status and other clinical characteristics with COVID-19 test results. JAMA network open. 2020 Sep 1;3(9):e2019722-. https://doi.org/10.1001/jamanetworkopen.2020.19722.
Kara M, Ekiz T, Ricci V, Kara Ö, Chang KV, Özçakar L. Scientific strabismus’ or two related pandemics: COVID-19 and vitamin D deficiency. British Journal of Nutrition, 2020; 124(7):736-741.
Bassi AG, Al-Rubaii BA. Detection of Pyocin S and the Effects of Lactobacillus Acidophilus Cell-Free Supernatants on Multi-Drug Resistant Pseudomonas Aeruginosa Isolated from Patients of Baghdad Hospitals. Journal of Communicable Diseases 2024; 56(1):135-144. https://doi.org/10.24321/0019.5138.202418.
Al-Jumaily RM, AL-Sheakli II, Muhammed HJ, Al-Rubaii BA. Gene expression of Interleukin-10 and Foxp3 as critical biomarkers in rheumatoid arthritis patients. Biomedicine. 2023 Aug 30;43(4):1183-7. https://doi.org/10.51248/.v43i4.3107
Sabah Fakhry S, Noori Hammed Z, Abdul-elah Bakir W, Abdullah Laftaah ALRubaii B. Identification of methicillin-resistant strains of Staphylococcus aureus isolated from humans and food sources by Use of mecA 1 and mecA 2 genes in Pulsedfield gel electrophoresis (PFGE (technique. Revis Bionatura 2022; 7 (2) 44.
Ali SM, Laftah BA, Al-Shammary AM, Salih HS. Study the role of bacterial neuraminidase against adenocarcinoma cells in vivo. InAIP Conference Proceedings 2021 Nov 11 (Vol. 2372, No. 1). AIP Publishing. https://doi.org/10.1063/5.0067193
Salih HS, Al-Shammari AM, Laftaah BA. Intratumoral co-administration of oncolytic newcastle disease virus and bacterial hyaluronidase enhances virus potency in tumor models. Journal of Global Pharma Technology. 2018; 10(10):303-310.
Muhsin HY, Al-Humairi RM, Alshareef DQ, Ad'hiah AH. Interleukin-22 is up-regulated in serum of male patients with ankylosing spondylitis. The Egyptian Rheumatologist. 2022 Oct 1;44(4):351-355. https://doi.org/10.1016/j.ejr.2022.07.002
Bresam S, Alhumairi RM, Hade IM, Al-Rubaii BA. Genetic mutation rs972283 of the KLF14 gene and the incidence of gastric cancer. Biomedicine. 2023 Aug 30; 43(4):1256-60. https://doi.org/10.51248/.v43i4.3112
Saleh TH, Hashim ST, Abdulrazaq Al-Obaidi RA, AL-Rubaii BA. A biological study of chitinase produced by clinical isolates of pseudomonas aeruginosa and detection of chia responsible gene. International Journal of Research in Pharmaceutical Sciences.2020; 11 (2):1318-1330. https://doi.org/10.26452/ijrps.v11i2.1989
Hamoode RH, Alkubaisy SA, Sattar DA, Hamzah SS, Saleh TH, Al-Rubaii BA. Detection of anti-testicular antibodies among infertile males using indirect immunofluorescent technique. Biomedicine. 2022 Nov 14; 42(5):978-982. https://doi.org/10.51248/.v42i5.1963
Mohsin MR, Al-Rubaii BA. Bacterial growth and antibiotic sensitivity of Proteus mirabilis treated with anti-inflammatory and painkiller drugs. Biomedicine. 2023;43(2):728-34. http://dx.doi.org/10.51248/.v43i02.2693
Mendy A, Apewokin S, Wells AA, Morrow AL. Factors associated with hospitalization and disease severity in a racially and ethnically diverse population of COVID-19 patients. MedRxiv, 2020; 541-548. https://doi.org/10.1101/2020.06.25.20137323
Yosef TM, Saleh SA, Ali SF, Ahmed AE. Vitamin D assessment in patients with COVID-19 virus and correlation with severity. The Egyptian Journal of Internal Medicine. 2022 Dec;34(1):52. https://doi.org/10.1186/s43162-022-00142-8
Salazar J, Martínez MS, Chávez-Castillo M, Núñez V, Añez R, Torres Y, Toledo A, Chacín M, Silva C, Pacheco E, Rojas J. C‐reactive protein: an in‐depth look into structure, function, and regulation. International scholarly research notices. 2014;2014(1):653045. https://doi.org/10.1155/2014/653045
Abbas MS, Ahmed AG, Ali SQ, AL-Rubaii BAL. Immunological inflammatory factors in patients diagnosed with COVID-19. Biomedicine,2023;43(Suppl.1):230-235.
Aygun H. Vitamin D can prevent COVID-19 infection-induced multiple organ damage. Naunyn-schmiedeberg's Archives of Pharmacology. 2020 Jul;393(7):1157-60. https://doi.org/10.1007/s00210-020-01911-4
Daneshkhah A, Agrawal V, Eshein A, Subramanian H, Roy HK, Backman V. Evidence for possible association of vitamin D status with cytokine storm and unregulated inflammation in COVID-19 patients. Aging clinical and experimental research. 2020 Oct;32:2141-58.DOI: https://doi.org/10.1007/s40520-020-01677-y.
Yuen KS, Ye ZW, Fung SY, Chan CP, Jin DY. SARS-CoV-2 and COVID-19: The most important research questions. Cell and Bioscience. 2020; 10:1-5. https://doi.org/10.1056/NEJMoa200203
Qu R, Ling Y, Zhang YH, Wei LY, Chen X, Li XM, Liu XY, Liu HM, Guo Z, Ren H, Wang Q. Platelet‐to‐lymphocyte ratio is associated with prognosis in patients with coronavirus disease‐19. Journal of medical virology. 2020 Sep;92(9):1533-41.
Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, Qiu Y, Wang J, Liu Y, Wei Y, Yu T. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. The lancet. 2020 Feb 15; 395(10223):507-13.
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Copyright (c) 2025 Noor Sallih Hallab, Reem Adeeb Mohammed, Inas Abd Al Majed Rasheed, Bahaa Abdullah Laftaah AL-Rubaii
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