EVALUATION OF EXOCRINE PANCREATIC FUNCTION IN PATIENTS WITH CHRONIC PANCREATITIS IN COMBINATION WITH HYPERTENSION
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Keywords

chronic pancreatitis, hypertension, exocrine function of the pancreas, pancreatic enzymes

How to Cite

ArhijЕ. J., Prylypko, L. B., & Halay, B. M. (2019). EVALUATION OF EXOCRINE PANCREATIC FUNCTION IN PATIENTS WITH CHRONIC PANCREATITIS IN COMBINATION WITH HYPERTENSION. Eastern Ukrainian Medical Journal, 7(1), 39-47. Retrieved from https://eumj.med.sumdu.edu.ua/index.php/journal/article/view/7

Abstract

Introduction and purpose. Research by the majority of scientists of the medical community proves the presence of combined pathologies, which implies further study of these conditions. One of these combinations is chronic pancreatitis (CP) and hypertension (H). Both diseases mutually worsen the course of each other. Therefore, the purpose of our study was to study the exocrine function of the pancreas (P) with the combination of CP and H.

Materials and methods. To study the mentioned problem, a comprehensive survey was conducted: 102 patients with CP in combination with H II stage, which formed the main group, and 23 practically healthy individuals who formed a control group, were examined. The evaluation of the external secretion function was carried out by measuring the elastase-1 level in stool and diastase level in urine; to establish the presence of "blood enzymes abnormalities" phenomenon, lipase and amylase blood levels were measured.

Results and discussion. Considering the sensitivity and specificity of the methods we used, the leading indicator of pancreas exocrine function in our study was the level of fecal eleastazy-1. The obtained results indicate that in the examined contingent of patients the external-secretion insufficiency prevails on the edge of moderate and mild severity (157.82 ± 17.28 mcg/g versus 203.47 ± 13.64 mcg/g in the control group, p < 0.01). Analyzing the diastase concentrations in the urine, amylase and lipase in the blood, it can be stated that there were no increase in the level of diastase in the urine, no amylase or lipase in the blood in the examined patients. Although the values of all three last indices significantly differed from those in the control group. The study of correlations showed a positive strong correlation between the concentration of diastase in the urine and lipase in the blood (r = 0.62, p < 0.01), diastase in the urine and amylase in the blood (r = 0.67, p < 0.01), direct strong correlation between the level of lipase and amylase (r = 0.54, p < 0.01) and a negative relationship between diastase concentration in urine and elastase-1 in feces (r = -0.20, p = 0.05) in the examined population.

Conclusions. The complex of patients' examination for CP in conjunction with H should include the study of exocrine function of the pancreas. In spite of the availability, cost and informative nature of the diagnostic methods we have studied, it is recommended to use the definition of FE-1 as a specific marker of the exocrine function of the pancreas.

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