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kidney, electrolyte, balance, relationship, blood

How to Cite

A. M. Loboda, O. I. Smiyan, S. V. Popov, V. O. Petrashenko, & D. A. Loboda. (2019). PECULIARITIES OF ELECTROLYTIC BALANCE IN THE BLOOD OF NEWBORNS WITH KIDNEY DAMAGE DUE TO ASPHYXIA. Eastern Ukrainian Medical Journal, 7(4), 341-350. Retrieved from


Introduction. The study of the concentration of main electrolytes in serum of blood and erythrocytes in neonates with impaired renal function due to asphyxia is important, because it allows determining violations of their content and balance, tactics of infusion and diuretic therapy. The purpose of the work is explore the features of the content and balance of electrolytes (sodium, potassium, calcium, magnesium) in serum and red blood cells of newborns with disturbance kidney function due to asphyxia.

Materials and methods. The study involved 200 term infants with signs of disturbance kidney function: 100 children who have suffered severe asphyxia, 100 children – with moderate asphyxia. Comparison group consisted of 20 infants without asphyxia at birth. The content of electrolytes determined by emission photometry, also expected ratios in pairs Na/K and Ca/Mg and transmembrane ratio of trace elements.

Results and discussion. The critical period of formation electrolyte imbalances in neonates with impaired renal function due to moderate asphyxia is the early neonatal period, in case of severe asphyxia – all neonatal period. The feature of ischemic renal impairment in newborns is the development of serum hypernatremia and hyperkalemia, hypocalcemia and hypomagnesemia, decrease the ratio of Na/K and increase Ca/Mg. Red blood cell pool of macroelements in case of neonatorum ischemic nephropathy is characterized by the growth of sodium level and deficiency of potassium, calcium and magnesium, as well as growth transmineralisation Na/K ratio and decrease Ca/Mg. Growth transmembrane ratios relative to sodium and magnesium reflects their transport into the cell, and reducing ratios relative potassium and calcium indicates the predominance of these electrolyte transport in the extracellular fluid. Changes in serum and intracellular electrolyte content and balance must be considered during infusion therapy in infants with impaired renal function due to asphyxia.

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1. Kurinczuk JJ, White-Koning M, Badawi N. Epidemiology of neonatal encephalopathy and hypoxic-ischaemic encephalopathy. Early Hum Dev. 2010; 86: 329–38. doi: 10.1016/j.earlhumdev.2010.05.010
2. Wall SN, Lee AC, Carlo W, Goldenberg R, Niermeyer S, Darmstadt GL et al. Reducing intrapartum-related neonatal deaths in low- and middle-income countries-what works? Semin Perinatol. 2010; 34: 395–407. doi: 10.1053/j.semperi.2010.09.009
3. Morales P, Bustamante D, Espina-Marchant P, Neira-Pena T, Gutiérrez-Hernández MA, Allende-Castro C et al. Pathophysiology of perinatal asphyxia: can we predict and improve individual outcomes? The EPMA Journal. 2011; 2(2): 211–230. doi: 10.1007/s13167-011-0100-3
4. Mohan PV, Pai PM. Renal insult in asphyxia neonatorum. Indian Pediatrics. 2000; 37: 1102–1106.
5. Skal'nyy AV. Khimicheskie elementy v fiziologii i ekologii cheloveka [Chemical elements in humah’s physiology and ecology]. – M.: ONIKS 21 vek: Mir, 2004. 216 р.
6. Avtsyn AP, Zhavoronkov AA, Rish MA, Strochkova LS. Mikroelementozy cheloveka: etiologiya, klassifikatsiya, organopatologiya [Human microelementoses: etiology, classification, organopathology]. M.: Meditsina Publ., 1991. 496 р.
7. Kulikova NYu, Chasha TV, Mozhaeva AN, Kuz'menko GN, Sitnikova OG. [Ischemic nephropathy in newborns, clinical and laboratory characteristics, prediction and early diagnostics]. Zdorov'ye rebenka. 2010; 2(23): 104-107.
8. Lapach SN, Chubenko AV, Babich PN. Statisticheskie metody v mediko-biologicheskikh issledovaniyakh s ispol'zovaniem Exel [Statistical methods in biomedical research using Excel]. K.: MORION Publ., 2001. 408 р.
9. Nazarenko GI, Kishkun AA. Klinicheskaya otsenka rezul'tatov laboratornykh issledovaniy [Clinical evaluation of laboratory results]. M.: Meditsina Publ., 2006. 544 р.
10. Basu P, Som S, Das H, Choudhuri N. Electrolyte status in birth asphyxia. Indian J. Pediatr. 2010; 77(3): 259–262. doi: 10.1007/s12098-010-0034-0
11. Sweetman DU, Riordan M, Molloy EJ. Management of renal dysfunction following term perinatal hypoxia-ischaemia. Acta Paediatr. 2013; 102 (3): 233–241. doi: 10.1111/apa.12116
12. Ng PC. Effect of stress on the hypothalamic-pituitary-adrenal axis in the fetus and newborn. J. Pediatr. 2011; 158 (2): 41–43. doi: 10.1016/j.jpeds.2010.11.012
13. Sologub TV, Romantsov MG, Chesnokova NP. Svobodnoradikal'nye protsessy i vospalenie (patogeneticheskie, klinicheskie i terapevticheskie aspekty) [Free-radical processes and inflammation (pathogenic, clinical and therapeutic aspects)]. M.: Akademiya estestvoznaniya Publ., 2008. 143 р.
14. Gromova OA. [Neurotrophic system of the brain: neuropeptides, macro- and microelements, neurotrophic drugs]. Mezhdunarodnyy nevrologicheskiy zhurnal. 2007; 2 (12): 94–106.
15. Sheybak MP. [Magnesium deficiency and its importance in childhood pathology]. Ros. vestn. perinatologii i pediatrii. 2003; 1: 45–47.
16. Ikari A, Okude C, Sawada H et al. Activation of a polyvalent cation–sensing receptor decreases magnesium transport via claudin–16. Biochim. Biophys. Acta. 2008; 1778 (1): 283–290. doi: 10.1016/j.bbamem.2007.10.002