FINDINGS ON THE CORRECTIVE EFFECT OF MINERAL DILUTED SODIUM CHLORIDE WATER FROM WELL NO. 1 OF OCHAKOV CITY UNDER THE CONDITIONS OF METABOLIC SYNDROME SIMULATION

Olena I. Bakholdina; Oleksiy Ya. Oleshko; Serhiy H. Gushcha; Natalya O. Yaroshenko

doi:10.21272/eumj.2021;9(3):275-283

Olena I. Bakholdina State Institution "Ukrainian Research Institute of Medical Rehabilitation and Balneology of the Ministry of Health of Ukraine", Odessa, Ukraine https://orcid.org/0000-0002-5989-2272
Oleksiy Ya. Oleshko State Institution "Ukrainian Research Institute of Medical Rehabilitation and Balneology of the Ministry of Health of Ukraine", Odessa, Ukraine https://orcid.org/0000-0001-6109-3579
Serhiy H. Gushcha State Institution "Ukrainian Research Institute of Medical Rehabilitation and Balneology of the Ministry of Health of Ukraine", Odessa, Ukraine https://orcid.org/0000-0003-3097-5258
Natalya O. Yaroshenko State Institution "Ukrainian Research Institute of Medical Rehabilitation and Balneology of the Ministry of Health of Ukraine", Odessa, Ukraine https://orcid.org/0000-0001-9066-8976

DOI: https://doi.org/10.21272/eumj.2021;9(3):275-283

Keywords: metabolic syndrome, endogenous intoxication, detoxification systems, mineral water, lipid-carbohydrate metabolism

Abstract

In the experiment, the effect of low-mineralized mineral diluted sodium chloride water with internal use on the body of animals with experimental metabolic syndrome (MS) was studied. 60 female white rats were divided into three groups of 20 animals each. Group 1 consisted of intact animals; group 2 consisted of animals with MS; group 3 consisted of animals with MS model, which received diluted mineral water (DMW).

Objective: to investigate the effect of diluted mineral sodium chloride water from well No. 1 of Ochakov on the state of the organism of rats with the MS model.

It was found that the development of the MS model in rats of group 2 was accompanied by a violation of lipid-carbohydrate metabolism (a significant increase in the content of glucose, cholesterol, triglycerides), impaired function of the urinary system, and a significant increase in the body weight of the animals. Signs of the development of endogenous intoxication were revealed – a significant increase in the level of circulating immune complexes and an increase in the level of molecules of average weight. The suppression of detoxification processes was established, as evidenced by a significant increase in the content of creatinine and urea (p < 0.05); that is, there is a cascade of pathological changes from various body systems, which proves that MS is a multiple organ pathology. In rats of the 3rd group, the use of DMW led to a limitation of the development of pathological processes: it was established that the indicators of carbohydrate and lipid metabolism were restored – the level of glucose, cholesterol, and triglyceride significantly decreased compared with the group of rats with uncorrected pathology. Weight gain was also significantly lower. The positive effect on the urine of the educational and excretory function of the kidneys, the restoration of the content of creatinine, urea, the level of average weight molecules, circulating immune complexes, and the activation of phagocytosis processes were determined, which contributed to a decrease in the intoxication load by increasing the detoxification capabilities of the body. The discovered effects indicate the presence of corrects the actions of the DMW in the conditions of experimental MS, which makes it possible to recommend further clinical trials.

Author Biographies

Olena I. Bakholdina, State Institution "Ukrainian Research Institute of Medical Rehabilitation and Balneology of the Ministry of Health of Ukraine", Odessa, Ukraine

ДУ «Український науково-дослідний інститут медичної реабілітації та курортології МОЗ України», завідувач КДЛ. E-mail: kdlkdl2017@gmail.com, тел.: (0482) 30-17-42, https://orcid.org/0000-0002-5989-2272

Oleksiy Ya. Oleshko, State Institution "Ukrainian Research Institute of Medical Rehabilitation and Balneology of the Ministry of Health of Ukraine", Odessa, Ukraine

к.мед.н., ДУ «Український науково-дослідний інститут медичної реабілітації та курортології МОЗ України», ст.н.співроб. E-mail: kdlkdl2017@gmail.com, тел.: (0482) 30-17-42, https://orcid.org/0000-0001-6109-3579

Serhiy H. Gushcha, State Institution "Ukrainian Research Institute of Medical Rehabilitation and Balneology of the Ministry of Health of Ukraine", Odessa, Ukraine

к.мед.н., ДУ «Український науково-дослідний інститут медичної реабілітації та курортології МОЗ України», в.о. завідуючого відділу фундаментальних досліджень E-mail: gushchasergey@rambler.ru, тел.: (048) 37-21-231, https://orcid.org/0000-0003-3097-5258

Natalya O. Yaroshenko, State Institution "Ukrainian Research Institute of Medical Rehabilitation and Balneology of the Ministry of Health of Ukraine", Odessa, Ukraine

ДУ «Український науково-дослідний інститут медичної реабілітації та курортології МОЗ України», завідувач лабораторії фізіології з віварієм. E-mail: fiziol_29@meta.ua, тел.: (0482) 30-17-38, https://orcid.org/0000-0001-9066-8976

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