INFLUENCE OF THYROID HORMONES AND CORTISOL ON IMMUNE RESPONSE IN CASE OF CHILDREN’S BRONCHOPULMONARY DISEASES
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Keywords

children, bronchopulmonary diseases, euthyroid sick syndrome, hormones, triiodothyronine, thyroxine, cortisol, immunity

How to Cite

Oleksandr Smiyan, Andriy Loboda, Anastasiia Havrylenko, Tatiana Bynda, Sergey Popov, Yurii Reznychenko, Olena Vasylieva, Viktoriia Petrashenko, Petro Sichnenko, Kateryna Smiian, Yuliia Man’ko, Iryna Shkolna, Tatiana Aleksakhina, & Yuliia Syadrista. (2021). INFLUENCE OF THYROID HORMONES AND CORTISOL ON IMMUNE RESPONSE IN CASE OF CHILDREN’S BRONCHOPULMONARY DISEASES. Eastern Ukrainian Medical Journal, 9(2), 189-201. https://doi.org/10.21272/eumj.2021;9(2):189-201

Abstract

The problem of acute respiratory tract infections (including acute bronchitis) remains urgent in the whole world independent of human age, especially when disease rates are considered. The World Health Organization reports annually on 1.5 billion cases of acute respiratory diseases. In Ukraine, the disease rate is 3.6 times higher among children than among adults (totally, it is equal to 67,000 cases per 100,000 individuals). The highest rate is observed among under-6-year-old children. In contrast to the average bronchopulmonary disease rate in Europe, the same Ukrainian index remains slightly higher for the last decades. Among children, the acute bronchitis rate is 6.2–25.0% within all bronchopulmonary diseases, reaching 50.0–90.0% if there are recurrences.

Our literature review aims to compare different researchers’ perspectives, selecting articles and analyzing data as to how thyroid hormones and cortisol influence immune response in children’s bronchopulmonary diseases. In the literature review, the modern perspective of children’s hormonal state in bronchopulmonary diseases is studied. The hypothalamus-hypophysis-thyroid and hypothalamus-hypophysis-paranephros interaction roles in bronchopulmonary adaptive responses are explained. The thyroid hormone and cortisol importance for organism resistance are regarded. The manifestation, pathogenetic progress mechanisms, diagnosing methods, and treatment of different subclinical hormonal shifts (particularly euthyroid sick syndrome) are researched. The interconnection of hormonal and immunological indicators is covered (whose change is a predictively significant marker – that can foresee the disease progress, its duration and consequences for patients). Therefore, the relevance consists in researching the influence of thyroid hormones and cortisol on immune response by different pathological states of children’s bronchopulmonary diseases.

https://doi.org/10.21272/eumj.2021;9(2):189-201
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References

1. Ahmed M. Al-Mokhtar, Abdulsamie H. Alta’ee, Naseer J. Al-Mokhtar and Mohammed K. Al-Hattab. Clinical association of thyroid hormones and psoriatic severity in patients with chronic plaque psoriasis. Biochemical and Cellular Archives. 2018;18(1):1415-1418.
2. Anaya JM, Shoenfeld Y, Rojas-Villarraga A, et al. Autoimmunity: From Bench to Bedside. Editors. Bogota (Colombia): El Rosario University Press; 2013.
3. Baranov AA. Sostoyanie zdorov'ya detej v Rossijskoj Federacii. Pediatriya. Zhurnal im. G. N. Speranskogo. 2012;91(3):15.
4. Berg V, Nost TH, Skeie G, Thomassen Y, Berlinger B, Hansen S, et al. Thyroid homeostasis in mother–child pairs in relation to maternal iodine status: the MISA study. Eur J Clin Nutr. 2017;71(8):1002-1007. Available from: doi: 10.1038/ejcn.2017.83.
5. Bhat K, Sharma S, Sharma K, Singh RK. Assessment of thyroid function in critically ill patients. Biomedical Research. 2016;27(2):449-452.
6. Bodnar PN, redaktor. Ehndokrinologiya. 2-e izdanie. Vinnytsia: Nova knyha Publ.; 2016. 488 p.
7. Boonen E, Bornstein SR, Berghe G Van den. New insights into the controversy of adrenal function during critical illness. Lancet Diabetes Endocrinol. 2015;3(10):805-815. Available from: doi.org/: 10.1016/S2213-8587(15)00224-7.
8. Borsukov AV, Kosova AA, Ivanov YUI, Andreeva OV, Smirnova EA. Lokal'noe lechenie uzlovogo zoba maloinvazivnym ehlektrokhimicheskim lizisom: pilotnye rezul'taty. Klinicheskaya i ehksperimental'naya tireoidologiya. 2010;6(1):46-53.
9. Canuto RA. Dehydrogenases. InTech; 2012. 366 p.
10. Cela I, Shah NB, Bradly D, loew J, Leslie W. An Epstein-Barr Virus–Associated Smooth Muscle Tumor Successfully Treated with Surgical Resection: A Case Report and Literature Review. Clinical Advances in Hematology & Oncology/ 2010;8(6):423-428.
11. Chenchak VA. Osobennosti dejstviya tiroksina na immunnuyu sistemu. Mezhdunarodnyj studencheskij nauchnyj vestnik [Internet]. 2017. [cited 2021 May 10];3. Available from: https://www.eduherald.ru/ru/article/view?id=17190
12. Chmyr NV. Rol shchytopodibnoi zalozy pry metabolichnomu syndromi ta v poiednanni z khronichnoiu ishemichnoiu khvoroboiu sertsia ta tsukrovym diabetom 2-ho typu. Mizhnarodnyi endokrynolohichnyi zhurnal. 2018;14(8):740-743. Available from: http://nbuv.gov.ua/UJRN/Mezh_2018_14_8_8
13. Chopra IJ. A study of exstrathyroidal conversion of thyroxine to 3,3",5-thriiodthyronine in vitro. Endocrinology. 1977;101:453-463. Available from: doi: 10.1210/endo-101-2-453.
14. Chopra IJ, Huang TS, Beredo A. et al. Evidence for an inhibitor of extrathyroidal conversion of thyroxin to 3,5,3'-triiodothyronine in sera of patients with nonthyroidal illness. J. Clin. Endocrinol. Met. 1985;60:666-671. Available from: doi: 10.1210/jcem-60-4-666.
15. Coutinho AE, Chapman KE. The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights. Molecular and Cellular Endocrinology. 2011;335(1):2-13. Available from: doi.org/: 10.1016/j.mce.2010.04.005
16. Danilkina OP. Fiziologiya stressa: metod. ukazaniya. Krasnoyarsk; 2015. 52 p.
17. Davydov MI, Gancev SHKH. Onkologiya : uchebnik. Moskva: GEHOTAR-Media Publ.; 2013. 920 p.
18. De Groot LJ. Dangerous dogmas in medicine: the nonthyroidal illness syndrome. The Journal of Clinical Endocrinology & Metabolism. 1999;84(1):151–164. Available from: doi:10.1210/jcem.84.1.5364
19. Dedov II. Rukovodstvo po ehndokrinologii. GEHOTAR-Media Publ.; 2021. 1112 p.
20. Deepak J, Puttaswamy RK, Krovvidi H. Non-respiratory functions of the lung. Continuing Education in Anaesthesia Critical Care & Pain. 2013;13(3):98-102. Available from: doi.org/ https://doi.org/10.1093/bjaceaccp/mks060.
21. Dubinina II. Ehndokrinologiya: Rukovodstvo dlya vrachej. Pod red. Potemkina VV. Moskva: MIA. 2013. Problemy ehndokrinologii. 2015;61(3):69-70. Available from: doi.org/10.14341/probl201561369-70
22. Dudnik OV, Orlova SN, Shibacheva NN, Kalistratova EP, Kopysheva EN, Mashin SA. Ostrye i khronicheskie virusnye gepatity v praktike uchastkovogo terapevta. Ivanovo; 2015. 108 p.
23. Ermashkevich SN, Petukhov VI, Kuncevich MV, Yangolenko VV, Tikhonova LV. Tireoidnyj status muzhchin s ostroj infekcionnoj destrukciej legkogo. Siberian scientific medical journal. 2020;40(4):44-52. Available from: doi: 10.15372/SSMJ20200406.
24. Federal'nye klinicheskie rekomendacii po diagnostike i lecheniyu bronkhial'noj astmy [Internet]. 2013. [cited 2021 May 10]. Available from: https://minzdrav.gov-murman.ru/documents/poryadki-okazaniya-meditsinskoy-pomoshchi/clinasthma22013(3).pdf
25. Federal'nye klinicheskie rekomendacii (protokoly) po vedeniyu detej s ehndokrinnymi zabolevaniyami. Moskva: Praktika Publ.; 2014. 442 p.
26. Feldt-Rasmussenab U, Effraimidisa G, Klosea M. The hypothalamus-pituitary-thyroid (HPT)-axis and its role in physiology and pathophysiology of other hypothalamus-pituitary functions. Molecular and Cellular Endocrinology/ 2021;525. Available from: doi.org/10.1016/j.mce.2021.111173.
27. Fliers E, Boelen A. An update on non-thyroidal illness syndrome. J Endocrinol Invest. 2020. Available from: doi.org/10.1007/s40618-020-01482-4.
28. Galkina OV, Prokopenko VM, Putilina FE, Eshchenko ND, Arutyunyan AV. Dejstvie izomerov tiroksina na processy svobodnoradikal'nogo okisleniya v subkletochnykh frakciyakh kory golovnogo mozga krys. Problemy Ehndokrinologii. 2000;46(4):32-34. Available from: doi.org/10.14341/probl11862.
29. Ganesan K, Wadud K. Euthyroid Sick Syndrome. StatPearls Publishing; 2021.
30. Gardner D, Shobek D. Bazisnaya i klinicheskaya ehndokrinologiya. V 2-kh knigakh. Binom Publ.; 2016. 696 p.
31. Glushakov RI, Kozyrko EV, Sobolev IV, Ermolova SA, Vlas'eva OV. Zabolevaniya shchitovidnoj zhelezy i risk vozniknoveniya netireoidnoj patologii. Kazanskij medicinskij zhurnal. 2017;98(1):77-84.
32. Halimov YUV, Rubcov YUE, Gusev RV, Chekhovskikh YUS, Kuz'mich VG. Vnebol'nichnaya pnevmoniya tyazhelogo techeniya: patofiziologicheskie osobennosti tireoidnogo statusa. Zdorov'e. Medicinskaya ehkologiya. Nauka. 2015;2(60):50-54.
33. Hamnueva LYU, Andreeva LS, Khantakova EA. Joddeficitnye zabolevaniya i sindrom gipotireoza: ehtiologiya, patogenez, diagnostika, lechenie : uchebnoe posobie. Irkutsk: IGMU; 2018. 59 p.
34. Havrylenko AO. [Analysis of mortality from acute infectious diseases of the respiratory organs in ukraine among children under 1 year during 2018-2019]. Tezy dopovidei 90-yi naukovo-praktychnoi konferentsii studentiv i molodykh vchenykh «Innovatsii v medytsyni ta farmatsii» [Abstract of the 90th Scientifi c Conference of Students and Young Scientists «Innovations in Medicine and Pharmacy»]. Ivano-Frankivsk, 2021, p. 78.
35. Havrylenko AO. [Analysis of the incidence of acute infectious diseases of the respiratory system in Ukraine among children under 1 year during 2018-2019]. Materialy XXV Mizhnarodnoho medychnoho konhresu studentiv ta molodykh vchenykh [Materials of the XXV International Medical Congress of Students and Young Scientists]. Ternopil: Ukrmedknyha, 2021, p. 148.
36. Hershman JM. Euthyroid Sick Syndrome. MSD Manual. Professional Version. Available from: https://www.msdmanuals.com/professional/endocrine-and-metabolic-disorders/thyroid-disorders/euthyroid-sick-syndrome [Accessed Sep 2020].
37. Hodosh EHM. Osobennosti lecheniya bronkhial'noj obstrukcii pri ostrom bronkhite. Ukrainskyi pulmonolohichnyi zhurnal. 2011;4:49-54.
38. Ivanov DO, Surkov DN, Mavropulo TK. Prakticheskie aspekty vodno-ehlektrolitnykh i ehndokrinnykh narushenij u detej rannego vozrasta. SPb.: Inform-Navigator Publ.; 2014. 368 p.
39. Jacobi J. Management of Endocrine Emergencies in the ICU. J Pharm Pract. 2019;32(3):314-326. Available from: doi: 10.1177/0897190019834771.
40. Ju W. The Endocrine System. Neuroscience: Canadian 1st Edition. Bains G, Barany I, Shcherbina M, Lee S. (eds). Pressbooks under a CC BY (Attribution) license. 2018. Available from: https://ecampusontario.pressbooks.pub/neurosciencecdn/chapter/anatomy-physiology-the-endocrine-system/
41. Kakucska I, Romero LL, Clark BD, et al. Suppression of thyrorotropin-releasing hormone gene expression by interleikin-1 beta in the rat: implications for nonthyroidal illness. Neuroendocrinology. 1994;59(2):129-137. Available from: doi.org/10.1159/000126649.
42. Kanji S, Neilipovitz J, Neilipovitz B, et al. Triiodothyronine replacement in critically ill adults with non-thyroidal illness syndrome. Canadian Journal of Anesthesia/Journal canadien d'anesthésie. 2018;65:1147–1153. Available from: doi.org/10.1007/s12630-018-1177-0.
43. Kaptein EM, Robinson WJ, Grieb DA, et al. Peripheral serum thyroxine, triiodothyronine and reverse triiodothyronine kinetics in the low thyroxine state of acute nonthyroidal illnesses. J. Clin. Invest. 1982;69:526-535. Available from: doi: 10.1172/jci110478.
44. Karlsson B, Gustafsson J, Hedov G, et al. Thyroid dysfunction in Down’s syndrome: relation to age and thyroid autoimmunity. Archives of Disease in Childhood. 1998;79:242-245.
45. Kel'cev VA. Funkcional'noe sostoyanie sistemy gipofiz-shchitovidnaya zheleza-kora nadpochechnikov u detej v razlichnye periody revmatizma. Nauchno-tekhnicheskij progress v razvitii ambulatorno-poliklinicheskoj pomoshchi naseleniyu.1984;77-78.
46. Kel'cev VA. Propedevtika detskikh boleznej. Vysshee medicinskoe obrazovanie. Rostov n/D : Feniks Publ.; 2011. 573 p.
47. Korneva EA. Puti vzaimodejstviya nervnoj i immunnoj sistem: istoriya i sovremennost', klinicheskoe primenenie. Medicinskaya immunologiya. 2020;22(3):405-418. Available from: doi.org/10.15789/1563-0625-PON-1974
48. Kotus J. Euthyroid Hyperthyroxinemia. Medscape. Available from: https://emedicine.medscape.com/article/118562-overview [Accessed 1st Feb 2018].
49. Krysiak R, Kędzia A, Kowalcze K, Okopień B. Euthyroid sick syndrome: an important clinical problem. Wiad Lek. 2017;70(2 pt 2):376-385.
50. Kusel'man AI, Solov'eva IL, Cherdancev AP. Gerpesvirusnye infekcii u detej: rukovodstvo dlya vrachej. Ul'yanovsk: ULGU; 2017. 280 p.
51. Laxer RM, Sherry DD. Pediatric rheumatology. Elsevier: Pediatric Clinics of North America. 2012. Available from: doi.org/10.1016/j.pcl.2012.03.015
52. Lee S, Farwell AP. Euthyroid Sick Syndrome. Compr Physiol. 2016;6(2):1071.
53. Litvickij PF. Patologiya ehndokrinnoj sistemy. Ehtiologiya i patogenez ehndokrinopatij: narusheniya funkcij shchitovidnoj i parashchitovidnykh zhelez. Nepreryvnoe professional'noe obrazovanie. 2012;11(1):61-75.
54. LiVolsi VA, Baloch ZW. The Pathology of Hyperthyroidism. Front Endocrinol (Lausanne). 2018;9:737. Available from: doi: 10.3389/fendo.2018.00737.
55. Luca R De, Davis PJ, Lin H-Y, et al. Thyroid Hormones Interaction With Immune Response, Inflammation and Non-thyroidal Illness Syndrome. Front Cell Dev Biol. 2021;8:614030. Available from: doi: 10.3389/fcell.2020.614030.
56. Lucassen PJ, Pruessner J, Sousa N, Almeida OFX, Dam AM Van, Rajkowska G, Swaab DF, Czéh B. Neuropathology of stress. Acta Neuropathologica. 2014;127:109-135.
57. Lysenko IM, Novikova VI, Barkun GK, Zhuravleva LN, et al. Bolezni detej rannego vozrasta. Posobie. Vitebsk: VGMU; 2014. 324 p.
58. MaKDermott MT. Sekrety ehndokrinologii. 4-e izd., isprav. i dopoln. Binom Publ.; 2021. 584 p.
59. Malagoli D, Ottaviani E. ACTH in invertebrates: a molecule for all seasons. Core. 2016;13:28-33. Available from: https://core.ac.uk/download/pdf/80171831.pdf [Accepted January 29, 2016].
60. Mal'ceva TA. Osobennosti funkcional'nogo sostoyaniya tireoidnogo statusa u bol'nykh bronkhial'noj astmoj (obzor literatury). Byulleten' fiziologii i patologii dykhaniya. 2012;44:117-123.
61. Mamenko MIe, Buhaienko OO, Somov SIu. Vplyv porushen tyreoidnoho statusu na rozvytok funktsionalnykh hastro-intestynalnykh rozladiv u ditei molodshoho shkilnoho viku. Sovremennaya pediatriya. 2014;6(62):116-120. Available from: doi:10.15574/SP.2014.62.116
62. Mebis L, Van den Berghe G. Thyroid axis function and dysfunction in critical illness. Best Practice & Research Clinical Endocrinology & Metabolism. 2011;25(5):745–757. Available from: doi:10.1016/j.beem.2011.03.002
63. Melmed S. et al. Williams Textbook of Endocrinology (Thirteenth Edition). Elsevier. 2016. Available from: doi.org/10.1016/C2013-0-15980-6
64. Metlay JP, Waterer GW, Long AC, et al. Diagnosis and Treatment of Adults with Community-acquired Pneumonia. An Official Clinical Practice Guideline of the American Thoracic Society and Infectious Diseases Society of America. American Journal of Respiratory and Critical Care Medicine. List of Issues. 2019;200(7):45-67. Available from: doi: 10.1164/rccm.201908-1581ST.
65. Mooradian AD, Reed RL, Osterweil D. et al. Decreased serum triiodthyronine is associated with increased concentrations of tumor necrosis factor. J. Clin. Endocrynol. Metab. 1990;71:1239-1242. Available from: doi:10.1210/jcem-71-5-1239.
66. Neto AM, Zantut-Wittmann DE. Abnormalities of Thyroid Hormone Metabolism during Systemic Illness: The Low T3 Syndrome in Different Clinical Settings. Int J Endocrinol. 2016;2016:2157583. Available from: doi:10.1155/2016/2157583.
67. Nistal-Nuño B. Euthyroid sick syndrome in paediatric and adult patients requiring extracorporeal circulatory support and the role of thyroid hormone supplementation: a review. Sage Journals. 2020;6(1):21-33. Available from: doi.org/10.1177/0267659120914136.
68. Oda Y, Mashita K, Mori-Tanaka M, et al. The inhibitory effect of noradrenaline on thyrotrophin-stimulated 3,5,3'-tri-iodothyronine and thyroxine release is mediated through a Ca(2+)-dependent process in the thyroid gland of the mouse. J. Endocrinol. 1993; 138(1):73-80. Available from: doi: 10.1677/joe.0.1380073.
69. Okayama D, Minami Y, Kataoka S, Shiga T, Hagiwara N. Thyroid function on admission and outcome in patients hospitalized for acute decompensated heart failure. Journal of Cardiology. 2015;66(3):205–211. Available from: doi:10.1016/j.jjcc.2015.04.006
70. Ortiga-Carvalho T M, Chiamolera MI, Pazos-Moura CC, Wondisford FE. Hypothalamus-Pituitary-Thyroid Axis. Compr Physiol. 2016;6(3):1387-428. Available from: doi: 10.1002/cphy.c150027.
71. Ovsyannikov DYU, Illarionova TYU, Pushko LV, Kuz'menko LG. Chasto boleyushchie deti: chto eshche krome infekcij? Voprosy sovremennoj pediatrii. 2013;12(1):74-86.
72. Pankiv V I.  Vzaiemozviazok patolohii shchytopodibnoi zalozy ta tsukrovoho diabetu. Zdorovia Ukrainy 21 storichchia. 2019;3(448):44-46.
73. Pasiechko NV, Yevstratieva YuV. Vzaiemozviazok mizh rivnem tyreotropnoho hormonu, insulinorezystentnistiu ta sertsevo-sudynnymy faktoramy ryzyku v patsiientiv z ozhyrinniam ta subklinichnym hipotyreozom. Mezhdunarodnyj ehndokrinologicheskij zhurnal. 2020;16(8):630-635. Available from: doi: 10.22141/2224-0721.16.8.2020.222879
74. Pavlishin GA, Kibar OD, Furdela VB, Galiyash NB, Sarapuk IM. Osobennosti metabolizma tireoidnykh gormonov u detej s vnebol'nichnoj pnevmoniej: sindrom ehutireoidnoj patologii i vnutrikletochnoe raspredelenie joda. Medicinskie novosti gruzii. 2018;3(276):60-65.
75. Pavlov VN, Fazlyeva RM, et al. Gemorragicheskaya likhoradka s pochechnym sindromom. Aktual'nye voprosy patogeneza, kliniki, diagnostiki i lecheniya. Moskva: GEHOTAR-Media Publ.; 2019. 160 p.
76. Pavlova OV, Kichigin VA, Madyanov IV. Funkcional'noe sostoyanie nadpochechnikov i shchitovidnoj zhelezy u bol'nykh khronicheskoj obstruktivnoj bolezn'yu legkikh. Vestnik Chuvashskogo universiteta. 2012;3:456-462.
77. Pavlova OV. Osobennosti funkcional'nogo sostoyaniya kory nadpochechnikov u bol'nykh khronicheskoj obstruktivnoj bolezn'yu legkikh [dissertaciya v Internete]. Moskva; 2017. [cited 2021 May 7]. Available from: https://www.dissercat.com/content/osobennosti-funktsionalnogo-sostoyaniya-kory-nadpochechnikov-u-bolnykh-khronicheskoi-obstruk
78. Peterkova VA, Vitebskaya AV, Geppe NA, et al. Spravochnik pediatra po detskoj ehndokrinologii: Metodicheskoe posobie. Moskva: Verdi Publ.; 2016. 140 p.
79. Peterson SB. Onkologiya: uchebnik. Moskva: GEHOTAR-Media Publ.; 2017. 288 p.
80. Pierce MJ, LaFranchi SH, Pinter JD. Characterization of thyroid abnormalities in a large cohort of children with down syndrome. Hormone Research in Paediatrics. 2017;87(3):170–178. Available from: doi:10.1159/000457952
81. Poll Van der T, Zee van K, Endert E, et al. Interleukin-1 receptor blockade does not affect endotoxin-induced changes in plasma thyroid hormone metabolism in man. J. Clin. Endocrynol. Metab. 1995;80:1341-1346. Available from: doi.org/10.1210/JCEM.80.4.7714108.
82. PPY Mak, WM But, CM Yu, CB Chow, KY Li, LP Lee, et al. Thyroid Dysfunction in Chinese Children and Adolescents with Down Syndrome. HK J Paediatr (new series). 2006;11:110-117.
83. Qiu Mingjing MD, Fang Min MD, Liu Xueyuan MD. Low free triiodothyronine levels predict symptomatic intracranial hemorrhage and worse short-term outcome of thrombolysis in patients with acute ischemia stroke. Medicine. 2017;96(45):e8539. Available from: doi:10.1097/MD.0000000000008539
84. Quatrini L, Ugolini S. New insights into the cell- and tissue-specificity of glucocorticoid actions. Cellular & Molecular Immunology. 2021;18:269-278. Available from: doi.org/10.1038/s41423-020-00526-2.
85. Rachina SA, Kozlov RS, Dekhnich NN, Bobylev AA, Barashko OD. Antibakterial'naya terapiya tyazheloj vnebol'nichnoj pnevmonii u vzroslykh: obzor rekomendacij i klinicheskie primery. Arkhiv vnutrennej mediciny. 2015;3(23):63-74.
86. Raznatovskaya OM, Bobrovnicha-Dvizova YUM. Klinicheskie osobennosti sochetannogo techeniya tuberkuleza legkikh s razlichnymi tipami sakharnogo diabeta. Zaporozhskij medicinskij zhurnal. 2017;6. Available from: doi.org/10.14739/2310-1210.2017.6.115014.
87. Rechkalov AV, Rechkalova OL. Vzaimosvyaz' psikhologicheskikh osobennostej lichnosti s gormonal'nymi sdvigami pri giperkinezii. Vestnik Nizhnevartovskogo gosudarstvennogo universiteta. 2019;1:129-136.
88. Rekomendacii EOK/EOA po diagnostike i lecheniyu dislipidemij 2016. Rossijskij kardiologicheskij zhurnal. 2017;5(145):7-77. Available from: https://scardio.ru/content/Guidelines/ESC-2016-dislipidemiya-5_rkj_17.pdf
89. Robin P. Peeters, Serge van der Geyten, Pieter J. Wouters, Veerle M. Darras, Hans van Toor, Ellen Kaptein, et al. Tissue thyroid hormone levels in critical illness. The Journal of Clinical Endocrinology & Metabolism. 2005;90(12):6498–6507. Available from: https://doi.org/10.1210/jc.2005-1013
90. Ruyatkina LA, Molchanova AA, Ruyatkina AS, Rozhinskaya LYA. Sindrom rezistentnosti k tireoidnym gormonam: trudnosti differencial'nogo diagnoza. Klinicheskaya i ehksperimental'naya tireoidologiya. 2018;14(1):39-46. Available from: doi.org/10.14341/ket9522
91. Samotrueva MA, Yasenyavskaya AL, Cibizova AA, Bashkina OA, Galimzyanov KHM, Tyurenkov IN. Nejroimmuno¬endokrinologiya: sovremennye predstavleniya o molekulyarnykh mekhanizmakh. Immunologiya. 2017;38(1):49-59. Available from: doi: 10.18821/0206-4952-2017-38-1-49-59
92. Samsygina GA, Vyzhlova EN. Eshche raz o problemakh ponyatiya «chasto boleyushchie detI». Pediatriya. 2016;95(4):209-215.
93. Shabalov NP. Neonatologiya (v 2 tomakh) 6-e izd. Moskva: GEHOTAR-Media Publ.; 2019. 1440 p.
94. Shustov SB. Ehndokrinologiya. SpeCLit; 2011. 832 p.
95. Smith DM, Hitchcock KR. Thyroid hormone binding to adult rat alveolar type II cells. An autoradiographic study. Exp. Lung. Res. 1983;5(2):141-153. Available from: doi.org/10.3109/01902148309061510.
96. Sternberg EM. Neuroendocrine regulation of autoimmune/inflammatory disease. J. Endocriinol. 2001;1(69):429-435. Available from: doi: 10.1677/joe.0.1690429.
97. Stoving RK. Mechanisms in endocrinology: Anorexia nervosa and endocrinology: a clinical update. European Journal of Endocrinology. 2018;180(1). Available from: doi:10.1530/EJE-18-0596.
98. Suda S, Muraga K, Kanamaru T, Okubo S, Abe A, Aoki J, Kimura K. Low free triiodothyronine predicts poor functional outcome after acute ischemic stroke. Journal of the Neurological Sciences. 2016;368:89–93. Available from: doi:10.1016/j.jns.2016.06.063
99. Sullivan, P. R. C., Bollinger, J. A. and Reichlin, S. 1973. Selective deficiency of tissue triiodothyronine: a proposed mechanism of elevated free thyroxine in the euthyroid sick. J. Clin. Invest. 52, 83a.
100. Tatochenko VK. Bolezni organov dykhaniya u detej. Prakticheskoe rukovodstvo. Borges; 2019. 300 p.
101. Tauesheva ZB, Tajzhanova DZH. Subklinicheskij gipotireoz. Medicina i ehkologiya. 2010;1:15-20.
102. Teppermen D. Fiziologiya obmena veshchestv i ehndokrinnoj sistemy. Moskva: Kniga po Trebovaniyu; 2013. 652 p.
103. Troshina EA, Mazurina NV, Yukina MYU, Ogneva NA. Vliyanie nekotorykh lekarstvennykh preparatov na funkciyu gipotalamo-gipofizarno-tireoidnoj sistemy i ehffektivnost' zamestitel'noj terapii tireoidnymi gormonami. Problemy ehndokrinologii. 2010;3:52-56.
104. Uwaifo GI, Hura DE. Hypercortisolism. StatPearls Publishing. Available from: https://www.ncbi.nlm.nih.gov/books/NBK551526/ [Accessed Jan 2021].
105. Vasil'ev VN, Kapilevich LV. Fiziologiya: uchebnoe posobie. Tomsk: Izd-vo Tomskogo politekhnicheskogo universiteta; 2010. 186 p.
106. Wajner SM, Maia AL. New Insights toward the Acute Non-Thyroidal Illness Syndrome. Front Endocrinol (Lausanne). 2012;3:8. Available from: doi: 10.3389/fendo.2012.00008.
107. Warner MH, Beckett GJ. Mechanisms behind the non-thyroidal illness syndrome: an update. Journal of Endocrinology. 2009;205(1):1–13. Available from: doi:10.1677/joe-09-0412
108. Wilmott RW, Bush A, Deterding R, Ratjen F, Sly P, Zar H, Li A. Kendig's. Disorders of the Respiratory Tract in Children. 9th Edition. Elsevier; 2018.
109. Zelman D. Understanding Juvenile Rheumatoid Arthritis – the Basics. Available from: https://www.webmd.com/rheumatoid-arthritis/understanding-juvenile-rheumatoid-arthritis-basics [Accessed 16th Jan 2021].
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