ENDOGENOUS INTOXICATION SYNDROME ACTIVITY IN BILIARY AUTONOMIC VISCERO-VISCERAL CARDIONEUROPATHY
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Keywords

gallbladder diseases, biliary autonomic viscero-visceral cardioneuropathy, endogenous intoxication syndrome, middle molecules

How to Cite

Larysa M. Strilchuk, & Marta O. Kondratyuk. (2021). ENDOGENOUS INTOXICATION SYNDROME ACTIVITY IN BILIARY AUTONOMIC VISCERO-VISCERAL CARDIONEUROPATHY. Eastern Ukrainian Medical Journal, 9(2), 151-156. https://doi.org/10.21272/eumj.2021;9(2):151-156

Abstract

Toxic excess of biologically active substances named middle molecules (MM), which include byproducts of normal and altered metabolism, products of inflammation and oxidation, bacterial remnants, antibodies and immunoactive substances, plays an important role in pathogenesis of gallbladder diseases and biliary autonomous viscero-visceral cardioneuropathy (BAVVCNP). In order to assess activity of the endogenous intoxication syndrome secondary to BAVVCNP, we examined 20 patients with coronary heart disease to determine the levels of MM in the blood (total and at 238, 254, 266, and 280 nm waves); the levels of MM in urine (at 238, 254, 266, 282, 288, and 310 nm waves) with calculation of aromaticity index (MM 238/280), peptide-nucleotide index (MM 238/266), distribution index (MM 280/254), and L-arginine, and nitrites of the urine. The results were statistically processed.

It was revealed that in case of BAVVCNP the severity of the endogenous intoxication syndrome was higher for all specific parameters of endotoxicosis, and especially for the total level of MM in blood (0.77 ± 0.13 units vs. 0.46 ± 0.13 units, p = 0.08), the MM level at 238 nm wave (1.53 ± 0.55 vs. 0.49 ± 0.06, p = 0.08) and hydrophilic MM level in the urine at 288 nm long waves (0.72 ± 0.12 vs. 0.40 ± 0.11, p = 0.05) and 310 nm (0.27 ± 0.08 vs. 0.10 ± 0.03, p <0.05). According to the literature, this may indicate an increase in levels of cholecystokinin, leptin, endothelin, proinflammatory interleukins and tumor necrosis factor α. According to the correlation analysis, activation of endogenous intoxication syndrome was associated with lipid distress syndrome, increased leptin content and accelerated renal filtration.

https://doi.org/10.21272/eumj.2021;9(2):151-156
Article PDF (Українська)

References

1. Kondratyuk MO, Sorokopud OO, Strіl'chuk LM, Zhakun ІB, Slaba OR, Besh OM, Radchenko OM, Leshchuk YL Chronic heart failure course prognosis depending on body weight and endogenous intoxication syndrome. Wiad Lek. 2019;72(4):527-531
2. Murakami M, Kano F, Murata M. LLO-mediated Cell Resealing System for Analyzing Intracellular Activity of Membrane-impermeable Biopharmaceuticals of Mid-sized Molecular Weight. Sci Rep. 2018;8(1):1946. doi: 10.1038/s41598-018-20482-2
3. Masakane I, Sakurai K.Masakane I, et al. Current approaches to middle molecule removal: room for innovation. Nephrol Dial Transplant. 2018;33(suppl_3):iii12-iii21. doi: 10.1093/ndt/gfy224
4. Chmielewski M, Cohen G, Wiecek A, Jesús Carrero J. The peptidic middle molecules: is molecular weight doing the trick? Semin Nephrol. 2014; 34(2):118-34. doi: 10.1016/j.semnephrol.2014.02.005
5. Bel'skaya LV, Kosenok VK, Massard G. Endogenous Intoxication and Saliva Lipid Peroxidation in Patients with Lung Cancer. Diagnostics (Basel).2016;6(4):39. doi: 10.3390/diagnostics6040039
6. Matsuda N, Hattori Y, Sakuraya F, Kobayashi M, Zhang XH, Kemmotsu O, Gando S. Hemodynamic significance of histamine synthesis and histamine H1- and H2-receptor gene expression during endotoxemia. Naunyn Schmidebergs Arch Pharmacol.2002; 366: 513-521. doi: 10.1152/ajplung.00164.2004
7. Vanholder R, De Smet R, Glorieux G, Argilés A, Baurmeister U, Brunet P et al. Review on uremic toxins: classification, concentration, and interindividual variability. Kidney Int. 2003;63(5):1934-43. doi: 10.1046/j.1523-1755.2003.00924.x
8. Jonkers IJ, Smelt AH, Ledeboer M, Hollum ME, Biemond I, Kuipers F, Stellaard F, Boverhof R, Meinders AE, Lamers CH, Masclee AA. Gall bladder dysmotility: a risk factor for gall stone formation in hypertriglyceridaemia and reversal on triglyceride lowering therapy by bezafibrate and fish oil. Gut. 2003;52(1):109-15. doi: 10.1136/gut.52.1.109
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