INFLUENCE OF METABOLIC SYNDROME ON KIDNEY FUNCTION IN PATIENTS WITH CHRONIC GOUT
The purpose of the study was to evaluate the influence of the metabolic syndrome on the features of clinical course, parameters of kidney function and severity of the inflammatory process in patients with long-term course of gout.
Materials and methods. We examined 30 patients with long-term gout and metabolic syndrome and 30 patients with gout without metabolic syndrome. All patients underwent anamnesis collection, physical examination, blood pressure measurements, anthropometric indices, laboratory tests: determination of uric acid level, creatinine, fasting plasma glucose, total cholesterol, triglycerides, cholesterol of high and low density lipoprotein, C-reactive protein, fibrinogen, erythrocyte sedimentation rate, calculation of glomerular filtration rate, general urine test, instrumental studies (ultrasound of the kidneys).
It was established that in gout associated with metabolic syndrome there was a more severe course of the disease, according to laboratory data, there was a significant difference in the rates of inflammation, which indicates the contribution of the metabolic syndrome to the intensity of the inflammatory process. The combination of gout and metabolic syndrome also had a negative effect on the function of the kidneys. Reduced renal function was detected in 63.3 % of patients in the main group and only in 36.7 % – in the group without metabolic syndrome which is reflected in changes in biochemical parameters and in the general analysis of urine. According to the ultrasonography of the kidneys, the concrements are found 23.4 % more often in patients with gout in the presence of metabolic syndrome.
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