PATHOMORPHOLOGICAL FEATURES OF BRAIN ASSOCIATED WITH SUICIDAL RISK IN PATIENTS WITH DEMENTIA

  • I. H. Mudrenko Medical Institute of Sumy State University, Sumy, Ukraine
Keywords: vascular dementia, mixed, with Alzheimer's disease, suicidal behavior, pathomorphological brain’s features, X-ray signs, computed tomography

Abstract

Purpose: definition of pathomorphological predictors regarding suicide in patients with dementia on the basis of neuroimaging analysis.

Materials and methods: 213 people with different clinical forms of dementia (vascular, due to Alzheimer's disease, mixed type) were examined. The СT scan method and the statistical processing method of results were used.

Research results: The article elucidates the relationship between the pathomorphological features in patients with various types of dementia and the risk of suicide. Thus, in Alzheimer's disease, the majority of patients in the groups compared had atrophic changes in the brain due to the neurodegenerative process such as atrophy of brain and cerebellum gyruses, expansion of subarachnoid spaces, deepening of the brain fissures. However, it has been determined that the existence of such X-ray changes as the decrease in brain matter density on the render of basal ganglia and white matter was observed in patients with low SR. That is, it can be assumed that joining vascular pathology as a chronic ischemia is a factor in the anti-risk of suicidal behavior in patients with Alzheimer’s disease.

In the vascular form of dementia process, the risk factor of suicide is the subcortical impression of brain white matter (leukoencephalopathy); mixed dementia – expansion of subarachnoid spaces, periventricular leukoareosis, expansion of brain bases , reduction of brain matter density on the render of basal ganglia, acute cerebrovascular event by hemorrhagic and ischemic types (rupture of aneurysms, cerebral infarction).

We assume that the existence of a more expressed organic impression of brain substance by the pathological neurodegenerative process and joining the vascular impression prevents the formation and implementation of SR.

The obtained data should be taken into account by clinicians for timely diagnosis and prevention of SR in patients with dementia.

References

1. Maruta NA, Mudrenko IH. Predictors of a suicidal behavior in patients with dementia. 25th European congress of psychiatry, European Psychiatry.2017; 41S:S365–S404.
2. Mudrenko IG. [Look at the sociological - psychological, psychological, psychopathological and legal law suicidogenesis during dementia and medical and social assistance]. Psixіatrіya, nevrologіya ta medichna psixologіya.2017; 2(8):33-39.
3. Mudrenko IG. [Biologic features formation of suicidal behavior at the ailments of the dementia (in terms of literature)]. Medicinskaya psixologiya.2017;12(4):63-68.
4. Haw CC, Harwood D, Hawton K. Dementia and suicidal behavior: a review of the literature International Psychogeriatrics. 2009; 21:440-453.
5. Draper BM. Suicidal behavior and assisted suicide in dementia. J. International Psychogeriatrics. 2015;27(10):1601-1611.
6. Saiko D.Yu. [Peculiarities of klіnіki і law іmrnostі formu psychic roses at a garden of Parkinson]. Ukraїnskij vіsnik psixonevrologії.2012; 3(72):54-58.
7. Seyfried LS, Kales HC, Ignacio RV, Conwell Y, Valenstein M. Predictors of suicide in patients with dementia. Alzheimers Dement. 2011;7:567–73. [PMC free article] [PubMed]
8. Stenager EN, Wermuth L, Stenager E, Boldsen J. Suicide in patients with Parkinson's disease: an epidemiological study. Acta Psychiatr Scand. 1994;90:70–72. [PubMed]
9. Weintraub D, Burn DJ. Parkinson's disease: the quintessential neuropsychiatric disorder. Movement disorders : official journal of the Movement Disorder Society.2011; 26(6):1022-31.
10. Yaxno NN, Zaxarov VV, Lokshina AB.[ Impaired memory and attention in old age]. Zhurnal nevrologii i psixiatrii.2006; 2:58-62.
11. Ventriglio AA, Gentile I, Bonfitto E, Stella M, Mari L. at al.. Suicide in the early stage of schizophrenia. Front. Psychiatry.2016;7:116.
12. Cyprien F, Courtet P, Malafosse A, Maller J, Meslin C, Bonafé A, Le Bars E, de Champfleur NM, Ritchie K, Artero S. Suicidal behavior is associated with reduced corpus callosum area. Biol Psychiatry. 2011.70(4):320-6. doi:10.1016/j.biopsych.2011.02.035
13. Hallam BJ, Brown WS, Ross C, Buckwalter JG, Bigler ED, Tschanz JT, Norton MC, Welsh-Bohmer KA, Breitner JC. Regional atrophy of the corpus callosum in dementia. J Int Neuropsychol Soc. 2008:14(3):414-23. doi: 10.1017/S1355617708080533.
14. Brüne M, Schöbel A, Karau R, Faustmann PM, Dermietzel R, Juckel G, Petrasch-Parwez E. Neuroanatomical correlates of suicide in psychosis: the possible role of von Economo neurons. PLoS One. 2011; 6(6):e20936. doi:10.1371/journal.pone.0020936.
15. Dombrovski, AY, Szanto K, Clark L, Reynolds CF, Siegle GJ. Reward Signals, Attempted Suicide, and Impulsivity in Late-Life Depression. JAMA Psychiatry.2013;70(10):10-17.
Published
2020-10-04
How to Cite
I. H. Mudrenko. (2020). PATHOMORPHOLOGICAL FEATURES OF BRAIN ASSOCIATED WITH SUICIDAL RISK IN PATIENTS WITH DEMENTIA. Eastern Ukrainian Medical Journal, 6(4), 416–423. Retrieved from https://eumj.med.sumdu.edu.ua/index.php/journal/article/view/109