PATHOMORPHOLOGICAL FEATURES OF BRAIN ASSOCIATED WITH SUICIDAL RISK IN PATIENTS WITH DEMENTIA
Purpose: definition of pathomorphological predictors regarding suicide in patients with dementia on the basis of neuroimaging analysis.
Materials and methods: 213 people with different clinical forms of dementia (vascular, due to Alzheimer's disease, mixed type) were examined. The СT scan method and the statistical processing method of results were used.
Research results: The article elucidates the relationship between the pathomorphological features in patients with various types of dementia and the risk of suicide. Thus, in Alzheimer's disease, the majority of patients in the groups compared had atrophic changes in the brain due to the neurodegenerative process such as atrophy of brain and cerebellum gyruses, expansion of subarachnoid spaces, deepening of the brain fissures. However, it has been determined that the existence of such X-ray changes as the decrease in brain matter density on the render of basal ganglia and white matter was observed in patients with low SR. That is, it can be assumed that joining vascular pathology as a chronic ischemia is a factor in the anti-risk of suicidal behavior in patients with Alzheimer’s disease.
In the vascular form of dementia process, the risk factor of suicide is the subcortical impression of brain white matter (leukoencephalopathy); mixed dementia – expansion of subarachnoid spaces, periventricular leukoareosis, expansion of brain bases , reduction of brain matter density on the render of basal ganglia, acute cerebrovascular event by hemorrhagic and ischemic types (rupture of aneurysms, cerebral infarction).
We assume that the existence of a more expressed organic impression of brain substance by the pathological neurodegenerative process and joining the vascular impression prevents the formation and implementation of SR.
The obtained data should be taken into account by clinicians for timely diagnosis and prevention of SR in patients with dementia.
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