THE ROLE OF LIQUID BIOPSY IN THE DIAGNOSIS OF ENDOMETRIAL CANCER: A BIBLIOMETRIC ANALYSIS

Nataliia  Hyriavenko; Roman  Moskalenko; Liudmyla  Kiptenko

doi:10.21272/eumj.2026;14(2);338-347

Nataliia Hyriavenko Department of Pathological Anatomy, Sumy State University, Sumy, Ukraine https://orcid.org/0000-0002-9805-014X
Roman Moskalenko Department of Pathological Anatomy, Sumy State University, Sumy, Ukraine https://orcid.org/0000-0002-2342-0337
Liudmyla Kiptenko Department of Morphology, Sumy State University, Sumy, Ukraine https://orcid.org/0000-0003-4886-3342

DOI: https://doi.org/10.21272/eumj.2026;14(2);338-347

Keywords: liquid biopsy, endometrial cancer, bibliometric analysis, ctDNA, biomarkers, oncogynecology

Abstract

Background. Liquid biopsy has emerged as one of the most promising approaches in modern oncological diagnostics, enabling the detection of tumor-derived components in biological fluids using minimally invasive methods. In recent years, this technique has attracted increasing attention in gynecologic oncology, particularly in the study of endometrial cancer.

Aim. Perform a bibliometric analysis of scientific publications dedicated to the application of liquid biopsy in endometrial cancer research.

Materials and methods. The analysis was conducted using the Scopus database and covered publications from 1956 to January 30, 2026.

Results. In total, 736 relevant documents were identified and analyzed. Bibliometric visualization and network analysis were performed using the software VOSviewer. The results demonstrated a significant increase in publications after 2016, indicating growing scientific interest in the clinical potential of liquid biopsy for cancer diagnostics and monitoring. Geographic analysis revealed that the largest contributions to this field come from China and the United States, followed by several European countries. Subject-area analysis showed a strong interdisciplinary nature to the research, with medicine, biochemistry, chemistry, computer science, and chemical engineering being the most represented disciplines. Cluster analysis identified four major research directions: oncology, gynecologic oncology, molecular biology, and diagnostic technologies. Chronological analysis revealed a gradual shift in research focus from traditional clinical diagnostic approaches to molecular and integrative technologies involving circulating tumor DNA, microRNA, and exosomes. gies involving circulating tumor DNA, microRNA, and exosomes.

Conclusions. The results confirm the growing scientific and clinical importance of liquid biopsy as a promising tool for early detection, monitoring, and personalized management of endometrial cancer.

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THE ROLE OF LIQUID BIOPSY IN THE DIAGNOSIS OF ENDOMETRIAL CANCER: A BIBLIOMETRIC ANALYSIS

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