ENDOGENOUS INTOXICATION SYNDROME ACTIVITY IN BILIARY AUTONOMIC VISCERO-VISCERAL CARDIONEUROPATHY

  • Larysa M. Strilchuk Department of Therapy No. 1, Medical Diagnostics and Hematology and Transfusiology, Lviv Danylo Halytsky National Medical University, Lviv, Ukraine
  • Marta O. Kondratyuk Department of Internal Medicine No. 2, Lviv Danylo Halytsky National Medical University, Lviv, Ukraine
Keywords: gallbladder diseases, biliary autonomic viscero-visceral cardioneuropathy, endogenous intoxication syndrome, middle molecules

Abstract

Toxic excess of biologically active substances named middle molecules (MM), which include byproducts of normal and altered metabolism, products of inflammation and oxidation, bacterial remnants, antibodies and immunoactive substances, plays an important role in pathogenesis of gallbladder diseases and biliary autonomous viscero-visceral cardioneuropathy (BAVVCNP). In order to assess activity of the endogenous intoxication syndrome secondary to BAVVCNP, we examined 20 patients with coronary heart disease to determine the levels of MM in the blood (total and at 238, 254, 266, and 280 nm waves); the levels of MM in urine (at 238, 254, 266, 282, 288, and 310 nm waves) with calculation of aromaticity index (MM 238/280), peptide-nucleotide index (MM 238/266), distribution index (MM 280/254), and L-arginine, and nitrites of the urine. The results were statistically processed.

It was revealed that in case of BAVVCNP the severity of the endogenous intoxication syndrome was higher for all specific parameters of endotoxicosis, and especially for the total level of MM in blood (0.77 ± 0.13 units vs. 0.46 ± 0.13 units, p = 0.08), the MM level at 238 nm wave (1.53 ± 0.55 vs. 0.49 ± 0.06, p = 0.08) and hydrophilic MM level in the urine at 288 nm long waves (0.72 ± 0.12 vs. 0.40 ± 0.11, p = 0.05) and 310 nm (0.27 ± 0.08 vs. 0.10 ± 0.03, p <0.05). According to the literature, this may indicate an increase in levels of cholecystokinin, leptin, endothelin, proinflammatory interleukins and tumor necrosis factor α. According to the correlation analysis, activation of endogenous intoxication syndrome was associated with lipid distress syndrome, increased leptin content and accelerated renal filtration.

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Author Biographies

Larysa M. Strilchuk, Department of Therapy No. 1, Medical Diagnostics and Hematology and Transfusiology, Lviv Danylo Halytsky National Medical University, Lviv, Ukraine

Стрільчук Лариса Миколаївна, кандидат медичних наук, доцент кафедри терапії № 1, медичної діагностики та гематології і трансфузіології Львівського національного медичного університету ім. Данила Галицького, larysa.stril4uk@ukr.net, 098-706-77-53

Marta O. Kondratyuk, Department of Internal Medicine No. 2, Lviv Danylo Halytsky National Medical University, Lviv, Ukraine

Кондратюк Марта Олексіївна, кандидат медичних наук, доцент кафедри внутрішньої медицини №2 Львівського національного медичного університету ім. Данила Галицького, dovholittia@gmail.com, 0322‑72-09-41

 

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Published
2021-06-29
How to Cite
1.
Larysa M. Strilchuk, Marta O. Kondratyuk. ENDOGENOUS INTOXICATION SYNDROME ACTIVITY IN BILIARY AUTONOMIC VISCERO-VISCERAL CARDIONEUROPATHY. East Ukr Med J [Internet]. 2021Jun.29 [cited 2024Mar.29];9(2):151-6. Available from: https://eumj.med.sumdu.edu.ua/index.php/journal/article/view/177