INFLUENCE OF METABOLIC SYNDROME ON KIDNEY FUNCTION IN PATIENTS WITH CHRONIC GOUT

  • M. Hrytsenko Odessa National Medical University, Odessa, Ukraine
Keywords: gout, metabolic syndrome, gouty nephropathy

Abstract

The purpose of the study was to evaluate the influence of the metabolic syndrome on the features of clinical course, parameters of kidney function and severity of the inflammatory process in patients with long-term course of gout.

Materials and methods. We examined 30 patients with long-term gout and metabolic syndrome and 30 patients with gout without metabolic syndrome. All patients underwent anamnesis collection, physical examination, blood pressure measurements, anthropometric indices, laboratory tests: determination of uric acid level, creatinine, fasting plasma glucose, total cholesterol, triglycerides, cholesterol of high and low density lipoprotein, C-reactive protein, fibrinogen, erythrocyte sedimentation rate, calculation of glomerular filtration rate, general urine test, instrumental studies (ultrasound of the kidneys).

It was established that in gout associated with metabolic syndrome there was a more severe course of the disease, according to laboratory data, there was a significant difference in the rates of inflammation, which indicates the contribution of the metabolic syndrome to the intensity of the inflammatory process. The combination of gout and metabolic syndrome also had a negative effect on the function of the kidneys. Reduced renal function was detected in 63.3 % of patients in the main group and only in 36.7 % – in the group without metabolic syndrome which is reflected in changes in biochemical parameters and in the general analysis of urine. According to the ultrasonography of the kidneys, the concrements are found 23.4 % more often in patients with gout in the presence of metabolic syndrome.

Downloads

Download data is not yet available.

References

1. Dalbeth N, Merriman TR, Stamp LK. Gout. The Lancet. 2016;388(10055):2039–2052. doi:10.1016/s0140-6736(16)00346-9
2. Svintsitskyy AS, Kozak NP, Ostafiichuk AS. [Pecularities of gouts’ course in association with the metabolic syndrome]. Ukr. revmatol. zh. 2011;46(4). Режим доступу: http://www.rheumatology.kiev.ua/article/1685
3. Kunitskaya NA. [Renal irritation at a combination of metabolic syndrome and gout at elderly patients]. Nefrologiya. 2013;17(1):98-101.
4. Roddy E, Choi H. Epidemiology of gout. Rheumatic Disease Clinics. 2014;40(2):155-175.
5. Katerenchuk IP, Tkachenko LA, Yarmola TI. Urazhennia nyrok pry revmatychnykh zakhvoryuvanniakh [Renal Impairment in Rheumatic Diseases]. Kyiv: Medknyha Publ., 2017. 144 p.
6. Taran OI. [Urate nephropathy and basic approaches to its treatment]. Pochky. 2013;2(04). Режим доступу: http://www.mif-ua.com/archive/article/36059
7. Richette P, Clerson P, Perissin L, Flipo RM, Bardin T. Revisiting comorbidities in gout: a cluster analysis. Annals of the rheumatic diseases. 2015;74(1):142-147. doi: 10.1136/annrheumdis-2013-203779 PMID: 24107981
8. González-Senac NM, Bailen R, Torres RJ, de Miguel E, Puig JG. Metabolic syndrome in primary gout. Nucleosides, Nucleotides and Nucleic Acids. 2014:33(4-6);185-191. doi: 10.1080/15257770.2013.853785 PMID: 24940668
9. Kim Y, Kang J, Kim GT. Prevalence of hyperuricemia and its associated factors in the general Korean population: an analysis of a population-based nationally representative sample. Clinical rheumatology. 2018:37(9);2529-2538. doi: 10.1007/s10067-018-4130-2 PMID: 29790110
10. Abdurashitova DI, Mamasaidov AT, Sakibaev KSh, Ismanov KM, Akhmatakhunova NA, Baymyrzayeva GO. [Gout and metabolic syndrome]. Vestnik Oshskogo gosudarstvennogo universiteta. 2015:3;29-36.
11. Billiet L, Doaty S, Katz JD, Velasquez MT. Review of hyperuricemia as new marker for metabolic syndrome. ISRN rheumatology. 2014. doi: 10.1155/2014/852954 PMID:24693449 PMCID:PMC3945178
12. Wei CY, Sun CC, Wei JC, Tai HC, Sun CA, Chung CF, Chou YC, Lin PL, Yang T. Association between hyperuricemia and metabolic syndrome: an epidemiological study of a labor force population in Taiwan. BioMed research international. 2015. doi: 10.1155/2015/369179 PMID: 26273611 PMCID: PMC4529909
13. Pol'skaya II, Marusenko IM, Vezikova NN. [Characteristic features of gout development in presence of metabolic syndrome]. Uchenyye zapiski Petrozavodskogo gosudarstvennogo universiteta. Biologicheskiye nauki. 2014;2 (139):52-58.
14. Krishnan E, Baker JF, Furst DE. Gout and the risk of acute myocardial infarction. Arthritis Rheum. 2006;54:2688–2696.
Published
2020-10-04
How to Cite
1.
M. Hrytsenko. INFLUENCE OF METABOLIC SYNDROME ON KIDNEY FUNCTION IN PATIENTS WITH CHRONIC GOUT. East Ukr Med J [Internet]. 2020Oct.4 [cited 2024Mar.29];6(4):447–452. Available from: https://eumj.med.sumdu.edu.ua/index.php/journal/article/view/113