DEPENDENCE OF THE ACTIVITY OF THE SYSTEM OF OXIDATIVE STRESS – ANTIOXIDANT PROTECTION ON INSULIN RESISTANCE IN PATIENTS WITH ESSENTIAL HYPERTENSION AND OBESITY

  • V. Psarova Sumy State University
Keywords: insulin resistance, oxidative stress, antioxidant protection, hypertension, obesity

Abstract

Relevance. The activation of free radical oxidative processes and the development of oxidative stress is one of the most important pathogenetic mechanisms of cardiovascular diseases. Active forms of oxygen can change cellular infiltration of vessels and endothelial function, having an impact on a functional condition of the adhesive molecules intercellular adhesion molecule-1 and vascular cell adhesion molecule-1. Under condition of insulin resistance (IR), the balance in the system of oxidative stress ­–­ antioxidant protection is disturbed, the result of which is insufficient resistance to the damaging effect of the LPO products.

The aim of the study was to assess the dependence of the activity of the system of oxidative stress – antioxidant protection on insulin resistance (IR) in patients with comorbidity of arterial hypertension and obesity.

We examined 200 patients with hypertension and class I–II obesity. The patients were divided into two groups depending on IR: the first group included 80 patients without IR and the second group – 120 patients with IR.

As the result of the study, it was established that the presence of IR affects the activity of the system of oxidative stress – antioxidant protection in comorbidity of hypertension and obesity. In the presence of IR, patients with hypertension and concomitant obesity have significantly higher levels of indicators of the system of oxidative stress (malondialdehyde (MDA) and diene conjugates (DC)) compared with patients without IR. In patients with comorbidity of hypertension and obesity, HOMA-IR directly correlated with the indicators of the oxidative stress system (MDA and DC) and inversely correlated with the indicator of total antioxidant protection. In hypertensive patients with obesity and no IR, an increase in HOMA-IR was associated with a decrease in total antioxidant protection, and in patients with IR, an increase in HOMA-IR was associated with an increase in MDA and DC, as well as a decrease in total antioxidant protection.

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References

1. Amirkhizi F, Siassi F, Minaie S. Is obesity associated with increased plasma lipid peroxidación and oxidative stress in women. ARYA Atheroscler. J. 2007;2:189–192.
2. Crea F, Camici PG, Bairey Merz CN. Coronary microvascular dysfunction: an update.Eur. Heart J. 2014;35(17):1101–1111.
3. Fernández-Sánchez A, Madrigal-Santillán E, Bautista M. Inflammation, oxidative stress, and obesity. J.A. Int. J. Mol. Sci. 2011;12:3117–3132.
4. Fujita K, Nishizawa H, Funahashi T.Systemic oxidative stress is associated with visceral fat accumulation and the metabolic syndrome. Circulation. 2006;70:1437–1442.
5. Furukawa S, Fujita T, Shimabukuro M. Increased oxidative stress in obesity and its impact on metabolic syndrome. J. Clin. Investig. 2004;114:1752–1761.
6. Іchihara K, Mogi M, Shibata R. Inflammation and Vascular Remodeling. Int. J. Vasc. Med. 2012;2012.ID 596796.
7. Saad MF, Rewers M, Selby J. Insulin resistance аnd hypertension. The Insulin Resistance Atherosclerosis study. Hypertention. 2004;43(6):1324–1331.
8. Chen Z, Vigueira PA, Chambers KT. Insulin resistance and metabolic derangements in obese mice are ameliorated by a novel peroxisome proliferator-activated receptor γ-sparing thiazolidinedione. J. Biol. Chem. 2012;287(28):23537–23548.
9. Khan N, Naz L, Yasmeen G. Obesity: An independent risk factor systemic oxidative stress. Pak. J. Pharm. Sci. 2006;19:Р. 62–69.
10. Lteif A, Vaishnava P, Baron AD. Endothelin limits insulin action in obese/insulin-resistant humans Diabetes. 2007;56:728–734.
11. Aroor AR, McKarns S, Demarco VG. Maladaptive immune and inflammatory pathways lead to cardiovascular insulin resistance. Metabolism. 2013;62(11):1543–1552.
12. Deussen A, Ohanyan V, Jannasch A. Mechanisms of metabolic coronary flow regulation. J. Mol. Cell. Cardiol. 2012;52(4):794–801.
13. Ertelt A, Barton A-K, Schmitz RR, Gehlen H. Metabolic syndrome: is equine disease comparable to what we know in humans? Endocr. Connect. 2014;3(3):R81–R93.
14. Shimamoto K, Miura T. Metabolic syndrome. Nippon Rinso. 2009;67(4):771–776.
15. Shoelson SE, Herrero L, Naaz A. Obesity, inflammation, and insulin resistance.Gastroenterology. 2007;132:2169–2180.
16. Hellsten Y, Nyberg M, Jensen LG, Mortensen SP. Vasodilator interactions in skeletal muscle blood flow regulation. J. Physiol. 2012;590(Pt 24):6297–6305.
17. Xu H, Barnes GT, Yang Q. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J. Clin. Investig. 2003;112:1821–1830.
Published
2019-12-29
How to Cite
1.
V. Psarova. DEPENDENCE OF THE ACTIVITY OF THE SYSTEM OF OXIDATIVE STRESS – ANTIOXIDANT PROTECTION ON INSULIN RESISTANCE IN PATIENTS WITH ESSENTIAL HYPERTENSION AND OBESITY. East Ukr Med J [Internet]. 2019Dec.29 [cited 2024Mar.29];7(4):323-8. Available from: https://eumj.med.sumdu.edu.ua/index.php/journal/article/view/52