@article{Ryndina_2019, title={CORRECTION OF DIASTOLIC DYSFUNCTION AND LEFT VENTRICULAR REMODELING PROCESSES IN PATIENT WITH RHEUMATOID ARTHRITIS IN COMBINATION WITH ARTERIAL HYPERTENSION}, volume={7}, url={https://eumj.med.sumdu.edu.ua/index.php/journal/article/view/9}, abstractNote={<p>Rheumatoid arthritis (RA) is recognized as an independent cardiovascular risk factor. The presence of arterial hypertension in patients with rheumatoid arthritis is associated with an unfavorable prognosis; the combination of diseases significantly interrelates to the course of each one. An important issue is the selection of complex therapy to correct diastolic dysfunction and left ventricular remodeling processes.</p> <p>The study involved 60 patients with RA in combination with hypertension, who were divided into two groups: group I and group II of 30 people each. All patients received basic therapy for RA, NSAIDs and GK. The control group III included 30 almost healthy people. Patients of group I additionally received ramipril 10 mg daily and amlodipine 5­–10&nbsp;mg daily.</p> <p>All patients from group I also received atorvastatin 20 mg daily and metabolic therapy of Mildronate 5 ml 0.5 g/5 ml intravenous drip per 200 ml sodium chloride solution 0.9&nbsp;% once a day for ten days, followed by a switch to capsules Mildronate 250 mg at a dose of 500 mg per day for 3 months. After repeated examination three months later, the patients of group I showed a decrease in myocardial mass index by 8.86&nbsp;% (р &lt; 0.05), decreased size of the left atrium by 5.52&nbsp;% (p &lt; 0.05), improved diastolic function: 13.33&nbsp;% of patients showed normalization, and 6,67&nbsp;% had type II diastolic dysfunction transition to type I (p &lt; 0.05). Also in the patients of group I with fluid in the pericardial cavity there was a decrease in the final diastolic size of the circular rim of the fluid by 46.6&nbsp;% (p &lt; 0.05). Patients in group II showed an increase in myocardial mass index by 3.33&nbsp;%, size of the left atrium by 8.68&nbsp;% (p &lt; 0.05) and the number of patients with diastolic dysfunction increased by 10&nbsp;% (p &lt; 0.05). The size of the circular rim of fluid in the patients of group II with fluid in the pericardial cavity increased by 6.67&nbsp;% (p &lt; 0.05).</p> <p>It can be concluded that such a scheme is relevant and can be re­commended in order to select rational complex therapy in patients with RA in combination with hypertension.</p&gt;}, number={1}, journal={East Ukr Med J}, author={Ryndina, N. G.}, year={2019}, month={Mar.}, pages={60-65} }