@article{Polina V. Kniazkova_Viktoriia Yu. Harbuzova_2022, title={ANALYSIS OF THE ASSOCIATION OF RS4977574-POLYMORPHIC VARIANTS OF THE ANRIL GENE WITH THE DEVELOPMENT OF ACUTE CORONARY SYNDROME IN INDIVIDUALS WITH DIFFERENT BODY MASS INDEX IN THE UKRAINIAN POPULATION}, volume={10}, url={https://eumj.med.sumdu.edu.ua/index.php/journal/article/view/250}, DOI={10.21272/eumj.2022;10(2):147-154}, abstractNote={<p>The <strong>objective</strong> was to analyze the association of rs4977574-polymorphic variants of the ANRIL gene with the development of acute coronary syndrome in individuals with different body mass index.</p> <p><strong>Materials and methods.</strong> The venous blood of 429 people (234 patients with acute coronary syndrome and 195 people in the control group) was used for the study. Genotyping of patients by rs4977574-polymorphic variants of the ANRIL gene was performed by real-time polymerase chain reaction (Real-time PCR) in the presence of TaqMan assay C_31720978_30. Statistical analysis of the results of the study was performed using SPSS software (version 17.0).</p> <p><strong>Results.</strong> The distribution of genotypes according to SNP rs4977574 of the ANRIL gene in the group of patients with ACS and the control group among individuals with BMI &lt; 25 kg/m<sup>2</sup> does not differ. Among patients with BMI 25 kg/m<sup>2 </sup>the genotype distribution of the rs4977574-polymorphic variant of the ANRIL gene was statistically significant (р = 0.035). In the group of patients with BMI &gt; 25 kg/m<sup>2 </sup>according to recessive (P<sub>observ</sub> = 0.014; OR<sub>observ</sub> = 1.876, 95 % СІ = 1.137–3.095) and additive (Р<sub>observ</sub> = 0.014; OR<sub>observ </sub>= 2.118, 95% СІ = 1.166–3.849) models of inheritance before making adjustment, people with G/G genotype had a double risk of acquiring ACS than carriers of the dominant allele. After the adjustment, corresponding models of inheritance had the same risk rate – for recessive model (Р<sub>adjust</sub> = 0.013; OR<sub>adjust</sub> = 1.951, 95% СІ = 1.149–3.313) and additive model (Р<sub>adjust</sub> = 0.026; OR<sub>adjust</sub> = 2.039, 95 % СІ = 1.087–3.826).</p> <p><strong>Conclusions.</strong> Individuals with BMI &gt; 25 kg/m<sup>2</sup>, which were carriers of G/G genotype had a 2 times higher risk to acquire ACS than the individuals with the dominant allele.</p> <p><strong>Prospects for further research. </strong>Further research will be aimed at studying the impact of ANRIL polymorphism upon the risk of ACS development depending on other risk factors.</p&gt;}, number={2}, journal={East Ukr Med J}, author={Polina V. Kniazkova and Viktoriia Yu. Harbuzova}, year={2022}, month={Jun.}, pages={147-154} }