@article{Yuliia V. Repchuk_Larysa P. Sydorchuk_2022, title={CORRELATIONS OF BODY MASS INDEX WITH CLINICAL AND LABORATORY INDICATORS IN PATIENTS WITH ESSENTIAL ARTERIAL HYPERTENSION DEPENDING ON AGT (RS699) GENE POLYMORPHISM}, volume={10}, url={https://eumj.med.sumdu.edu.ua/index.php/journal/article/view/236}, DOI={10.21272/eumj.2022;10(1):71-79}, abstractNote={<p><strong>The aim.</strong> To analyze the correlations between body mass index (BMI) and clinical and laboratory parameters in patients with essential hypertension (EAH) depending on <em>AGT</em> gene (rs699) polymorphism.</p> <p><strong>Materials and methods.</strong> The case-control study involved 72 patients with stage II EAH, 1–3 degrees of blood pressure (BP), high and very high cardiovascular risk (CVD) (29.16% (21) men, 70.84% ​​(51) women). The mean age of patients was 59.87 ± 7.98 y.o. The control group consisted of 48 healthy individuals comparable in age and gender. Polymorphism of the <em>AGT</em> gene (rs699) was detected by polymerase chain reaction. BMI was defined as the ratio of weight to square of height (kg/m<sup>2</sup>).</p> <p><strong>Results.</strong> The correlation matrix showed a direct relationship between BMI and anthropometric parameters of waist circumference (WC), hip circumference (HC) and WC/HC ratio (r = 0.70–0.81; p ≤ 0.022), vitamin D level (r = 0,65; p = 0.043) and the reverse with the level of ionized Ca<sup>2+</sup> in the blood (r = -0.71; p = 0.02) among TT-genotype carriers; in TC-genotype carriers BMI was directly related to WC and HC (r = 0.68; p &lt; 0.001 and r = 0.84; p &lt; 0.001), as well as the level of parathyroid hormone (PTH) (r = 0,43; p = 0.004), with a negative correlation with the level of vitamin D (r = -0.38; p = 0.011); in CC-genotype carriers, a direct link was found between BMI and WC and HC (r = 0.73; p &lt; 0.001 and r = 0.78; p &lt; 0.001).</p> <p><strong>Conclusions.</strong> Thus, the correlation matrix showed that BMI directly depended on the anthropometric parameters of WC, HC and/or WC/HC (r = 0.68-0.84; p ≤ 0.022-0.001) regardless of the <em>AGT</em> gene genotypes (r = 0,52-0.86; p ≤ 0.02-0.001) and inversely correlated with the ionized Ca<sup>2+</sup> level in the blood (r = -0.71; p = 0.02), but only in TT-genotype carriers of the <em>AGT</em> gene (rs699).</p&gt;}, number={1}, journal={East Ukr Med J}, author={Yuliia V. Repchuk and Larysa P. Sydorchuk}, year={2022}, month={Mar.}, pages={71-79} }