@article{Oleksandr Smiyan_Andriy Loboda_Anastasiia Havrylenko_Tatiana Bynda_Sergey Popov_Yurii Reznychenko_Olena Vasylieva_Viktoriia Petrashenko_Petro Sichnenko_Kateryna Smiian_Yuliia Man’ko_Iryna Shkolna_Tatiana Aleksakhina_Yuliia Syadrista_2021, title={INFLUENCE OF THYROID HORMONES AND CORTISOL ON IMMUNE RESPONSE IN CASE OF CHILDREN’S BRONCHOPULMONARY DISEASES}, volume={9}, url={https://eumj.med.sumdu.edu.ua/index.php/journal/article/view/181}, DOI={10.21272/eumj.2021;9(2):189-201}, abstractNote={<p>The problem of acute respiratory tract infections (including acute bronchitis) remains urgent in the whole world independent of human age, especially when disease rates are considered. The World Health Organization reports annually on 1.5&nbsp;billion cases of acute respiratory diseases. In Ukraine, the disease rate is 3.6 times higher among children than among adults (totally, it is equal to 67,000 cases per 100,000 individuals). The highest rate is observed among under-6-year-old children. In contrast to the average bronchopulmonary disease rate in Europe, the same Ukrainian index remains slightly higher for the last decades. Among children, the acute bronchitis rate is 6.2–25.0% within all bronchopulmonary diseases, reaching 50.0–90.0% if there are recurrences.</p> <p>Our literature review aims to compare different researchers’ perspectives, selecting articles and analyzing data as to how thyroid hormones and cortisol influence immune response in children’s bronchopulmonary diseases. In the literature review, the modern perspective of children’s hormonal state in bronchopulmonary diseases is studied. The hypothalamus-hypophysis-thyroid and hypothalamus-hypophysis-paranephros interaction roles in bronchopulmonary adaptive responses are explained. The thyroid hormone and cortisol importance for organism resistance are regarded. The manifestation, pathogenetic progress mechanisms, diagnosing methods, and treatment of different subclinical hormonal shifts (particularly euthyroid sick syndrome) are researched. The interconnection of hormonal and immunological indicators is covered (whose change is a predictively significant marker – that can foresee the disease progress, its duration and consequences for patients). Therefore, the relevance consists in researching the influence of thyroid hormones and cortisol on immune response by different pathological states of children’s bronchopulmonary diseases.</p&gt;}, number={2}, journal={East Ukr Med J}, author={Oleksandr Smiyan and Andriy Loboda and Anastasiia Havrylenko and Tatiana Bynda and Sergey Popov and Yurii Reznychenko and Olena Vasylieva and Viktoriia Petrashenko and Petro Sichnenko and Kateryna Smiian and Yuliia Man’ko and Iryna Shkolna and Tatiana Aleksakhina and Yuliia Syadrista}, year={2021}, month={Jun.}, pages={189-201} }